Clustering of certain cardiometabolic risk factors is known as metabolic syndrome (MetS). MetS is associated with an unhealthy lifestyle and the prevalence is increasing alongside the obesity epidemic, making it an important public health issue. Both MetS and obesity are common in the adult population in rural Northern Norway, which comprises an ethnically mixed population. MetS is defined using ...

<p>The vaginal inflammation and infection are one of the major female health issues, and unfortunately rather neglected. The anatomical structure and physiological conditions make vagina vulnerable to inflammation and infection, which if not successfully treated, can lead to deteriorating female health conditions. In pregnant patients, the pregnancy outcome can be severely affected. Although a ...

Sexual behavior is innately motivated and rewarding. The underlying neurobiological mechanisms of sexual motivation, copulation, and sexual reward have not been completely unraveled. This thesis gives insight in the structure, organization, and neurobiological orchestration of male rat sexual behavior. The research presented in this thesis demonstrates that a more extensive behavioral annotation ...

This study explores how internal student evaluation of teaching, courses and programmes at eight health profession education programmes are carried out and used. Student evaluation is a mandatory part of quality assurance systems in Norway and is meant to be used in educational quality assurance and enhancement. At the university of this study, these evaluations are also considered part of students’ ...

<p>Background: Denervation of renal sympathetic nerves (RDN) is a mini-invasive endovascular procedure introduced as an antihypertensive treatment with a potentially beneficial effect on insulin resistance. In this open-label non-randomized study we investigated non-diabetic patients with true treatment-resistant hypertension defined as office systolic blood pressure (BP)>140 mmHg and (mean) daytime ...

Venous thromboembolism (VTE), a collective term for deep vein thrombosis and pulmonary embolism, is a severe and multifactorial disease. Heritability has been found to explain up to 60% of VTE events, however, the role of genetics on VTE in cancer is scarcely studied. VTE occurs frequently in cancer patients and is a common cause of morbidity and mortality in this patient group. The aim of the present ...

Scientific abstract Antibiotic resistance, especially in Gram-negative pathogens, represents a substantial clinical and financial burden to our society. The presented work investigated mechanisms and evolutionary dynamics that promote the emergence and maintenance of resistance in bacteria. In the first study, conserved collateral susceptibility changes were identified across resistant uropathogenic ...

Physical activity is an important modifiable lifestyle factor that can improve general health and reduce the risk of disease. Currently, collecting data on physical activity in epidemiological studies are generally limited to long-term but self-reported and inaccurate physical activity questionnaires and/or using short-term but objective and more accurate accelerometers. Consumer-based activity ...

<p>Background: Osteoporotic fractures constitute a major health- and economic burden worldwide and because of an aging population the burden is estimated to rise. The individual consequences of fractures are severe. Norway has one of the highest fracture incidences in the world. The etiology of fracture risk at old age is less optimal bone mass accumulation in childhood and adolescence, rapid ...

The aim of this thesis was to develop a prognostic model for unfavorable outcome 12 months after surgical treatment of a lumbar disc herniation (lumbar microdiscectomy). While the surgical procedure is rather uniform, with little technical variation, the reported outcomes are quite heterogenous. This might be due to different expectations by patients, or due to suboptimal surgical indication as ...