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dc.contributor.advisorSkalko-Basnet, Natasa
dc.contributor.authorNguyen, Truc Phuong
dc.date.accessioned2013-06-19T13:19:14Z
dc.date.available2013-06-19T13:19:14Z
dc.date.issued2012-05-20
dc.description.abstractSkin injuries represent an important health problem that needs to be managed properly in order to avoid serious consequences in terms of morbidity, disability and life quality. The current focus in wound therapy is on upholding the moisture balance in the wound bed and protection against pathogenic invasion. Wound dressings in a form of hydrogels incorporating antimicrobials, such as the antibiotic mupirocin, can be applied to control dermal infections and thereby ensure optimal wound healing. Drug-in-liposomes-in-hydrogel may additionally provide prolonged contact between drug and wounded area, reducing the need for frequent application of wound dressing. Size analysis of sonicated liposomes indicated that the particles were smaller than 300 nm, optimal for topical administration onto the skin. Assessment of anti-biofilm effect of liposomally entrapped and free mupirocin showed that both formulations had an impact on biofilm formation and planktonic bacteria, however no clear advantage of liposomal formulation over free drug was seen. Liposomal hydrogels in which mupirocin is incorporated in liposomes, are safe and have potential to be used as wound dressing assuring maintenance of a moist wound environment. Chitosan liposomal hydrogels would be recommended for wounds with exudates, as their absorbing properties were better than for Carbopol-based hydrogels.en
dc.identifier.urihttps://hdl.handle.net/10037/5215
dc.identifier.urnURN:NBN:no-uit_munin_4929
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2012 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDFAR-3901en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736en
dc.subjectsåren
dc.subjectwounden
dc.subjectinfeksjonen
dc.subjectinfectionen
dc.subjectsårforbindingen
dc.subjectwound dressingen
dc.subjectliposomeren
dc.subjectliposomesen
dc.subjecthydrogeleren
dc.subjecthydrogelsen
dc.subjectmupirosin kalsiumen
dc.subjectmupirocin calciumen
dc.titleOptimization of antimicrobial wound dressings: liposomal hydrogels with mupirocinen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)