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norskArtikler, rapporter og annet (medisinsk biologi): Recent submissions
Now showing items 801-820 of 1059
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Behovsmedisinering i sykehjem: Forskrivning, bruk og dokumentasjon av effekt.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Bakgrunn: For å sikre sykehjems-pasienter effektiv og forsvarlig legemiddelbehandling, kreves hensiktsmessige rutiner for forskrivning, håndtering og effektdokumentasjon både av legemidler gitt fast og ved behov. Vår kunnskap om forholdene rundt behovsmedisinering er begrenset. Hensikt: Få kunnskap om behovsmedisinering ved å kartlegge forskrivning og utlevering av behovslegemidler ved ett utvalgt ... -
Overdiagnosis of breast cancer in the Norwegian Breast Cancer Screening Program estimated by the Norwegian Women and Cancer cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: There is increasing ambiguity towards national mammographic screening programs due to varying publicized estimates of overdiagnosis, i.e., breast cancer that would not have been diagnosed in the women’s lifetime outside screening. This analysis compares the cumulative incidence of breast cancer in screened and unscreened women in Norway from the start of the fully implemented Norwegian ... -
Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-20)Background: Salmon trypsin is shown to increase secretion of the pro-inflammatory cytokine interleukin (IL)-8 from human airway epithelial cells through activation of PAR-2. Secretion of IL-8 induced by king crab trypsin is observed in a different concentration range compared to salmon trypsin, and seems to be only partially related to PAR-2 activation. This report aim to identify differences in ... -
Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were ... -
Level of selected toxic elements in meat, liver, tallow and bone marrow of young semi-domesticated reindeer (Rangifer tarandus tarandus L.) from Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objectives. To gain knowledge on toxic elements in semi-domesticated reindeer and their distribution in meat, liver, tallow and bone marrow. The correlations between concentrations in meat and liver, as well as the use of the latter as an indicator for toxic elements in meat, were also investigated. Study design. Cross-sectional study on population of semi-domesticated reindeer from 2 northern ... -
Persistent organic pollutants in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Background: The aim of this project was to study 14 polychlorinated biphenyls (PCBs), 5 dichlorodiphenyl trichloroethans (DDTs), 12 organochlorine pesticides (OCPs) and 6 polybrominated diphenylethers (PBDEs) in meat, liver, tallow and bone marrow from semi-domesticated reindeer. Methods: Meat, liver, tallow, and bone marrow samples (n= 30) were collected from semi-domesticated reindeer in Northern ... -
Level of selected nutrients in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer t. tarandus L.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Objectives: To acquire new knowledge on the nutritional composition of semi-domesticated reindeer (Rangifer t. tarandus L.) and their nutritional value for humans. The results could be useful in updating the Norwegian Food Composition Database, whose current data on reindeer is limited. Study design: Cross-sectional study on population of semi-domesticated reindeer from 2 northern Norwegian counties ... -
Motivation to persist with internet-based cognitive behavioural treatment using blended care: a qualitative study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)The prevalence of depression is high and results in huge costs for society. Internet-based cognitive behavioural treatment (ICBT) has been suggested for use in primary care and has been shown to be more effective when combined with human support. However, non-completion rates remain a challenge. Current recommendations state that steps to improve persistence with ICBT should be determined and the ... -
High referral rates to secondary care by general practitioners in Norway are associated with GPs' gender and specialist qualifications in family medicine, a study of 4350 consultations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Referral rates of general practitioners (GPs) are an important determinant of secondary care utilization. The variation in these rates across GPs is considerable, and cannot be explained by patient morbidity alone. The main objective of this study was to assess the GPs’ referral rate to secondary care in Norway, any associations between the referral decision and patient, GP, health care characteristics ... -
Ethnic difference in the prevalence of angina pectoris in Sami and non-Sami populations: the SAMINOR study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Objective: To assess the population burden of angina pectoris symptoms (APS), self-reported angina and a combination of these, and explore potential ethnic disparity in their patterns. If differences in APS were found between Sami and non-Sami populations, we aimed at evaluating the role of established cardiovascular risk factors as mediating factors. Design: Cross-sectional population-based ... -
HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions
(Conference object; Konferansebidrag, 2013)In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ... -
Hepatitis B and C viruses and survival from hepatocellular carcinoma in the Arkhangelsk region: a Russian registry-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Introduction. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The prevalence of hepatitis B (HBV) and C (HCV) in Russia was 7.6 and 5.4 per 100,000, respectively. The aim of this study was to assess the proportion of HCV and HBV infection among HCC patients, to evaluate associations between HCV, HBV and stage of HCC and to compare survival of HCC patients by their HBV/HCV ... -
Long-Term Use of Lipid-Lowering Drugs Slows Progression of Carotid Atherosclerosis The Tromso Study 1994 to 2008
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Data on the effect of lipid-lowering drugs (LLD) on carotid atherosclerosis outside clinical trials are limited. The aim of this study was to determine the effect of LLD on change in carotid intima media thickness and total plaque area in a general population. Subjects were 1532 women and 1442 men who participated in a longitudinal population-based study with ultrasound examination of intima media ... -
Doctors are to blame for perceived medical adverse events. A cross sectional population study. The Tromsø study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Most current knowledge of the incidence of medical adverse events (AEs) comes from studies carried out in hospital settings. Little is known about AEs occurring outside hospitals, in spite the fact that most of contacts between patients and health care take place in primary care. Small sample population studies report that 4–49% of the general public have experienced AEs related to their own or ... -
What professional activities do general practitioners find most meaningful? Cross sectional survey of Norwegian general practitioners
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Health reforms in many countries affect the scope and nature of primary care. General Practitioners (GPs) are expected to spend more time developing public health, preventive health care, coordination of care and teamwork. We aimed to explore which professional activities GPs consider to be meaningful and how they would like to prioritise tasks. In a cross sectional online survey 3,270 GPs were ... -
Human endogenous retroviruses and cancer prevention: evidence and prospects
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers ... -
Vertebral fractures and self-perceived health in elderly women and men in a population-based cross-sectional study: the Tromsø Study 2007-08
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Health-related quality of life (HRQL) may be associated with increased mortality in the elderly. The effect of prevalent vertebral fractures on HRQL in elderly women and men is not well described. The purpose of this study was to examine the association between prevalent vertebral fractures and back pain, neck pain, and HRQL in elderly women and men, and to study possible gender differences in the ... -
Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 ... -
Sex differences in mortality of admitted patients with personality disorders in North Norway - a prospective register study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)It is well established that patients with serious mental disorders have higher mortality than the general population, yet there are few studies on mortality of both natural and unnatural causes in patients with personality disorders. The aim of this study was to investigate the mortality of in-patients with personality disorder diagnosis in a 27-year follow-up cohort in North Norway, with a special ... -
Prevalence and population structure of Staphylococcus aureus nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Healthcare workers (HCWs) may be a reservoir for Staphylococcus aureus transmission to patients. We examined whether HCW status is associated with S. aureus nasal carriage and population structure (spa types) in 1302 women (334 HCWs) and 977 men (71 HCWs) aged 30–69 years participating in the population-based Tromsø Study in 2007–2008. Multivariable logistic regression models were used. While no ...
