Artikler, rapporter og annet (medisinsk biologi): Nye registreringer

Viser treff 1021-1040 av 1059

    • Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study 

      Dumeaux, vanessa; Nuel, G; Børresen-Dale, Anne-Lise; Olsen, Karina Standahl; Paulssen, Ruth H; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Understanding unexpected courses of multiple sclerosis among patients using complementary and alternative medicine : A travel from recipient to explorer 

      Salamonsen, Anita; Launsø, Laila; Kruse, Tove Elisabeth; Eriksen, Sissel H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • The health related quality of life of people living with HIV/AIDS in sub-Saharan Africa - a literature review and focus group study 

      Robberstad, Bjarne; Olsen, Jan Abel (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Effect of Unfractionated Heparin on TFPI Elimination 

      Øie, Cristina Ionica; Appa, Rupa Shree; Brodin, Ellen; Hilden, Ida; Smedsrød, Bård; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel, 2010)
      Background: Tissue factor pathway inhibitor (TFPI) plays an important role for the anticoagulant effect of heparin. Depletion of intravascular TFPI by treatment with unfractionated heparin (UFH), and not by low molecular weight heparin (LMWH), has been suggested to explain the superiority of LMWH in treatment of both arterial and venous thrombosis. The present study was undertaken to investigate ...

    • Asialoglycoprotein Receptor (ASGP-R) is Liver Parenchymal Cells is Involved in Elimination of Recombinant Human TFPI 

      Appa, Rupa Shree; Øie, Cristina Ionica; Brodin, Ellen; Hansen, John-Bjarne; Smedsrød, Bård (Journal article; Tidsskriftartikkel, 2010)
      We here report on a study carried out to determine the early clearance kinetics, and organ, cell(s) and receptor(s) responsible for the clearance of full length TFPI purified from BHK cells (TFPI<sup>BHK</sup>). Following intravenous administration, <sup>125</sup>I-TFPI<sup>BHK</sup> was cleared with a biphasic elimination curve, and with a significantly slower t<sub>1/2</sub>α compared to recombinant ...

    • Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis 

      Zykova, Svetlana N.; Tveita, Anders Aune; Rekvig, Ole Petter (Tidsskriftartikkel; Peer reviewed; Journal article, 2010-08-10)
      Background: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice. As this may represent a basic mechanism in the progression of lupus nephritis, several aspects of ...

    • Prognostic Impact of Fibroblast Growth Factor 2 in NSCLC : Co-Expression with VEGFR-3 and PDGF-B Predicts Poor Survival 

      Dønnem, Tom; Al-Shibli, Khalid; Al-Saad, Samer; Busund, Lill-Tove; Bremnes, Roy M. (Tidsskriftartikkel; Peer reviewed; Journal article, 2009-05)
      Purpose: Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis. Murine studies have indicated a close interplay between both FGF2 and platelet-derived growth factor –B (PDGF-B) as well as FGF2 and vascular endothelial growth factor -3 (VEGFR-3). This study investigates the prognostic impact ...

    • Silencing Viral MicroRNA as a Novel Antiviral Therapy? 

      Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-03-20)
      Viruses are intracellular parasites that ensure their existence by converting host cells into viral particle producing entities or into hiding places rendering the virus invisible to the host immune system. Some viruses may also survive by transforming the infected cell into an immortal tumour cell. MicroRNAs are small non-coding transcripts that function as posttranscriptional regulators of gene ...

    • Matrix metalloproteinases in subjects with type 1 diabetes 

      Winberg, Jan-Olof; Gharagozlian, Sedegheh; Svennevig, Katja; Bangstad, Hans-Jacob; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-16)
      Background: Nephropathy is serious complication of diabetes. We have previously shown that level of the proteoglycan syndecan-1 in blood is associated with ultrastructural kidney changes in young persons with type 1 diabetes. Dysregulation of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) may contribute to the development of nephropathy. The aim of ...

    • Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure 

      Ravna, Aina W.; Sylte, Ingebrigt; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-04)
      The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of <i>Escherichia coli</i> MsbA, which were constructed in order to elucidate differences in the electrostatic and molecular features of their drug ...

    • In vitro host range, multiplication and virion forms of recombinant viruses obtained from co-infection in vitro with a vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus isolate 

      Tryland, Morten; Okeke, Malachy Ifeanyi; Nilssen, Øivind; Moens, Ugo; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-05-12)
      Background: Poxvirus-vectored vaccines against infectious diseases and cancer are currently under development. We hypothesized that the extensive use of poxvirus-vectored vaccine in future might result in co-infection and recombination between the vaccine virus and naturally occurring poxviruses, resulting in hybrid viruses with unpredictable characteristics. Previously, we confirmed that ...

    • The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells 

      Fadnes, Bodil Irene; Rekdal, Øystein; Uhlin-Hansen, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-06-15)
      Background: Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We have previously shown that CAPs interact with the two glycosaminoglycans (GAGs), ...

    • Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep 

      Langbakk, Bodil; Wærhaug, Kristine; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Ingebretsen, Ole C.; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)
      Introduction: Acute lung injury often complicates severe sepsis. In Gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human ...

    • Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis 

      Tveita, Anders Aune; Rekvig, Ole Petter; Zykova, Svetlana N. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-01)
      Lupus nephritis is a major contributor to morbidity and mortality in systemic lupus erythematosus, but little is known about the pathogenic processes that underlie the progressive decay in renal function. A common finding in lupus nephritis is thickening of glomerular basement membranes associated with immune complex deposition. It has been speculated that alterations in the synthesis or ...

    • Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis 

      Khan, Mahmud Tareq Hassan; Penolazzi, Letizia; Lampronti, Ilaria; Borgatti, Monica; Khan, Mahmud Tareq Hassan (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-10-30)
      Background: Osteoclasts (OCs) are involved in rheumatoid arthritis and in several pathologies associated with bone loss. Recent results support the concept that some medicinal plants and derived natural products are of great interest for developing therapeutic strategies against bone disorders, including rheumatoid arthritis and osteoporosis. In this study we determined whether extracts of Emblica ...

    • The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay 

      Hjerde, Erik; Holden, Matthew TG; Seeger, Kathy; Lorentzen, Marit Sjo; Bason, Nathalie; Paulsen, Steinar; Willassen, Nils Peder; Churcher, Carol; Harris, David; Norbertczak, Halina; Quail, Michael A; Sanders, Suzanne; Thurston, Scott; Parkhill, Julian; Thomson, Nicholas R (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-19)
      <b>Background:</b> The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo.<BR><BR> <b>Results:</b> In total, 4 286 protein coding sequences were identified, and the 4.6 Mb genome of A. salmonicida has a six partite architecture with two chromosomes and four ...

    • The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFα and a TNFα 36–62 Peptide 

      Rekdal, Ø.; Espevik, T.; Konopski, Z.; Svendsen, J. S.; Winberg, J.-O.; Østerud, B. (Journal article; Tidsskriftartikkel; Peer reviewed, 1994)
      The present study was performed to examine whether residues 36–62 of TNFα contain the chemotactic domain of TNFα, and whether the p55 and p75 TNF receptors are involved in TNFα induced chemotaxis. The chemotactic effect of TNFα on PMN was inhibited by the mAbs Hrt-7b and Utr-1, against the p55 and p75 TNF receptors, respectively. Both receptors may therefore be required for mediating the chemotactic ...

    • 14th International Symposium on Cells of the Hepatic Sinusoid 

      Smedsrød, Bård (Book; Bok, 2008-08-31)
      Abstract book of the symposium

    • Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer Postgenome Cohort : a cross-sectional analysis 

      Waaseth, Marit; Bakken, Kjersti; Dumeaux, Vanessa; Olsen, Karina Standahl; Rylander, Charlotta; Figenschaug, Yngve; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-14)
      Background: Hormone replacement therapy use (HRT) is associated with increased breast cancer risk. Our primary objective was to explore hormone levels in plasma according to HRT use, body mass index (BMI) and menopausal status. A secondary objective was to validate self-reported questionnaire information on menstruation and HRT use in the Norwegian Women and Cancer postgenome cohort (NOWAC). Methods: ...

    • Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination 

      Johansen, Steinar D.; Mjelle, Kenneth A.; Karlsen, Bård O.; Jørgensen, Tor Erik; Moum, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-01-11)
      Background: Halibuts are commercially important flatfish species confined to the North Pacific and North Atlantic Oceans. We have determined the complete mitochondrial genome sequences of four specimens each of Atlantic halibut (Hippoglossus hippoglossus), Pacific halibut (Hippoglossus stenolepis) and Greenland halibut (Reinhardtius hippoglossoides), and assessed the nucleotide variability within ...