Show simple item record

dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorBreivik, Knut
dc.contributor.authorFuskevåg, Ole-Martin
dc.contributor.authorNieboer, Evert
dc.contributor.authorOdland, Jon Øyvind
dc.contributor.authorSandanger, Torkjel Manning
dc.date.accessioned2014-03-24T08:31:19Z
dc.date.available2014-03-24T08:31:19Z
dc.date.issued2013
dc.description.abstractBackground: Longitudinal monitoring studies of persistent organic pollutants (POPs) in human populations are important to better understand changes with time and age, and for future predictions. Objectives: We sought to describe serum POP time trends on an individual level, investigate age–period–cohort effects, and compare predicted polychlorinated biphenyl (PCB) concentrations to measured values. Methods: Serum was sampled in 1979, 1986, 1994, 2001, and 2007 from a cohort of 53 men in Northern Norway and analyzed for 41 POPs. Time period, age, and birth cohort effects were assessed by graphical analyses and mixed-effect models. We derived the predicted concentrations of four PCBs for each sampling year using the CoZMoMAN model. Results: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1986, 1994, 2001, and 2007 relative to 1979 were –22%, –52%, –54%, and –68%, respectively. We observed substantial declines in all POP groups with the exception of chlordanes. Time period (reflected by sampling year) was the strongest descriptor of changes in PCB-153 concentrations. Predicted PCB-153 concentrations were consistent with measured concentrations in the study population. Conclusions: Our results suggest substantial intraindividual declines in serum concentrations of legacy POPs from 1979 to 2007 in men from Northern Norway. These changes are consistent with reduced environmental exposure during these 30 years and highlight the relation between historic emissions and POP concentrations measured in humans. Observed data and interpretations are supported by estimates from the CoZMoMAN emission-based model. A longitudinal decrease in concentrations with age was evident for all birth cohorts. Overall, our findings support the relevance of age–period–cohort effects to human biomonitoring of environmental contaminants.en
dc.identifier.citationEnvironmental Health Perspectives 121(2013) nr. 11-12 s. 1292-1298en
dc.identifier.cristinIDFRIDAID 1072176
dc.identifier.doihttp://dx.doi.org/10.1289/ehp.1206317
dc.identifier.issn0091-6765
dc.identifier.urihttps://hdl.handle.net/10037/6070
dc.identifier.urnURN:NBN:no-uit_munin_5770
dc.language.isoengen
dc.publisherNational Institute of Environmental Health Sciencesen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.titlePersistent Organic Pollutants in Norwegian Men from 1979 to 2007: Intraindividual Changes, Age–Period–Cohort Effects, and Model Predictionsen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record