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dc.contributor.authorStar, Bastiaan
dc.contributor.authorNederbragt, Alexander Johan
dc.contributor.authorJentoft, Sissel
dc.contributor.authorGrimholt, Unni
dc.contributor.authorMalmstrøm, Martin
dc.contributor.authorGregers, Tone Fredsvik
dc.contributor.authorRounge, Trine Ballestad
dc.contributor.authorPaulsen, Jonas
dc.contributor.authorSolbakken, Monica Hongrø
dc.contributor.authorSharma, Animesh
dc.contributor.authorWetten, Ola Frang
dc.contributor.authorLanzén, Anders
dc.contributor.authorWiner, Roger
dc.contributor.authorKnight, James
dc.contributor.authorVogel, Jan-Hinnerk
dc.contributor.authorAken, Bronwen
dc.contributor.authorAndersen, Øivind
dc.contributor.authorLagesen, Karin
dc.contributor.authorTooming-Klunderud, Ave
dc.contributor.authorEdvardsen, Rolf
dc.contributor.authorKirubakaran, G. Tina
dc.contributor.authorEspelund, Mari
dc.contributor.authorNepal, Chirag
dc.contributor.authorPreviti, A. Christopher
dc.contributor.authorKarlsen, Bård Ove
dc.contributor.authorMoum, Truls
dc.contributor.authorSkage, Morten
dc.contributor.authorBerg, Paul Ragnar
dc.contributor.authorGjøen, Tor
dc.contributor.authorKuhl, Heiner
dc.contributor.authorThorsen, Jim
dc.contributor.authorMalde, Ketil
dc.contributor.authorReinhardt, Richard
dc.contributor.authorDu, Lei
dc.contributor.authorJohansen, Steinar Daae
dc.contributor.authorSearle, Steve
dc.contributor.authorLien, Sigbjørn
dc.contributor.authorNilsen, Frank
dc.contributor.authorJonassen, Inge
dc.contributor.authorOmholt, Stig W
dc.contributor.authorStenseth, Nils Christian
dc.contributor.authorJakobsen, Kjetill Sigurd
dc.date.accessioned2015-10-15T11:48:27Z
dc.date.available2015-10-15T11:48:27Z
dc.date.issued2011-08-10
dc.description.abstractAtlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture1, 2. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end libraries, and automated annotation identified 22,154 genes. The major histocompatibility complex (MHC) II is a conserved feature of the adaptive immune system of jawed vertebrates3, 4, but we show that Atlantic cod has lost the genes for MHC II, CD4 and invariant chain (Ii) that are essential for the function of this pathway. Nevertheless, Atlantic cod is not exceptionally susceptible to disease under natural conditions5. We find a highly expanded number of MHC I genes and a unique composition of its Toll-like receptor (TLR) families. This indicates how the Atlantic cod immune system has evolved compensatory mechanisms in both adaptive and innate immunity in the absence of MHC II. These observations affect fundamental assumptions about the evolution of the adaptive immune system and its components in vertebrates.en_US
dc.identifier.citationNature 477(2011) nr. 7363 s. 207-210en_US
dc.identifier.cristinIDFRIDAID 834476
dc.identifier.doi10.1038/nature10342
dc.identifier.issn0028-0836
dc.identifier.urihttps://hdl.handle.net/10037/8215
dc.identifier.urnURN:NBN:no-uit_munin_7794
dc.language.isoengen_US
dc.publisherMacmillan Publishers Ltd.en_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en_US
dc.subjectGenetics and genomicsen_US
dc.subjectImmunologyen_US
dc.subjectMolecular biologyen_US
dc.subjectEvolutionen_US
dc.titleThe genome sequence of Atlantic cod reveals a unique immune systemen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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