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dc.contributor.authorChilmonczyk, Zdzislaw
dc.contributor.authorBojarski, Andrzej Jacek
dc.contributor.authorPilc, Andrzej
dc.contributor.authorSylte, Ingebrigt
dc.date.accessioned2016-03-09T14:59:21Z
dc.date.available2016-03-09T14:59:21Z
dc.date.issued2015
dc.description.abstractSerotonin (5-HT) is a monoamine neurotransmitter that plays an important role in physiological functions. 5-HT has been implicated in sleep, feeding, sexual behavior, temperature regulation, pain, and cognition as well as in pathological states including disorders connected to mood, anxiety, psychosis and pain. 5-HT1A receptors have for a long time been considered as an interesting target for the action of antidepressant drugs. It was postulated that postsynaptic 5-HT1A agonists could form a new class of antidepressant drugs, and mixed 5-HT1A receptor ligands/serotonin transporter (SERT) inhibitors seem to possess an interesting pharmacological profile. It should, however, be noted that 5-HT1A receptors can activate several different biochemical pathways and signal through both G protein-dependent and G protein-independent pathways. The variables that affect the multiplicity of 5-HT1A receptor signaling pathways would thus result from the summation of effects specific to the host cell milieu. Moreover, receptor trafficking appears different at pre- and postsynaptic sites. It should also be noted that the 5-HT1A receptor cooperates with other signal transduction systems (like the 5-HT1B or 5-HT2A/2B/2C receptors, the GABAergic and the glutaminergic systems), which also contribute to its antidepressant and/or anxiolytic activity. Thus identifying brain specific molecular targets for 5-HT1A receptor ligands may result in a better targeting, raising a hope for more effective medicines for various pathologies.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.3390/ijms160818474>http://doi.org/10.3390/ijms160818474</a>.en_US
dc.identifier.citationInternational Journal of Molecular Sciences 2015, 16(8):18474-18506en_US
dc.identifier.cristinIDFRIDAID 1277217
dc.identifier.doi10.3390/ijms160818474
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/8819
dc.identifier.urnURN:NBN:no-uit_munin_8364
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rights.accessRightsopenAccess
dc.subjectserotonin 1A receptorsen_US
dc.subjectreceptor traffickingen_US
dc.subjectantidepressant activityen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.titleFunctional selectivity and antidepressant activity of serotonin 1A receptor ligandsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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