This is the pre-peer reviewed version of the following article: Besada, E. and Diamantopoulos, A. P. (2015), Does Concomitant Methotrexate During Rituximab Treatment in Granulomatosis With Polyangiitis (Wegener's) Increase the Risk of Severe Infection? Comment on the Article by Azar et al. Arthritis & Rheumatology, 67: 1981–1982., which has been published in final form at http://dx.doi.org/10.1002/art.39144. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.