Individual fatty acids and cardiovascular risk factors

Abstract

This thesis focuses on the relationship of individual fatty acids in blood phospholipids with blood pressure, serum cholesterol, triglycerides and apolipoproteins. A clinical trial and a observational study address the following questions:

1. What are the effects of dietary supplementation with high doses (4 grams daily) of highly purified EPA and DHA on serum lipids (triglycerides, total, LDL and HDL cholesterol, apolipoprotein A and B), serum phospholipid fatty acid concentrations, blood pressure, heart rate and left ventricular performance in middle aged healthy men?

2. What is the cross-sectional relationship of plasma phospholipid fatty acids concentrations with blood pressure, serum triglycerides and total cholesterol among 40-42 year old men who participated in a population study?