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norskInstitutt for klinisk medisin: Recent submissions
Now showing items 1361-1380 of 1801
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Involuntary psychiatric admission: how the patients are detected and the general practitioners' expectations for hospitalization. An interview-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-08)<p>Background: In Norway, it is usually GPs that refer patients to involuntary admission. A high proportion of such referrals come from out-of-hours clinics. Little is known about who first initiate the contact between the patients and the referring doctors and which expectations the referring doctors have with respect to the involuntary admissions. The aim of the study was to examine who first ... -
Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ... -
How Do Elderly Poor Prognosis Patients Tolerate Palliative Concurrent Chemoradiotherapy for Locally Advanced NoneSmall Cell Lung Cancer Stage III? A Subset Analysis From a Clinical Phase III Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05)In a phase III trial of patients with unresectable stage III nonesmall-cell lung cancer and a poor prognosis, palliative concurrent chemoradiotherapy (CRT) provided a significantly better outcome than chemotherapy alone, except among performance status 2 patients. The results of the present exploratory subgroup analysis indicate that elderly patients with poor prognosis can also experience ... -
Fatal injuries in rural and urban areas in northern Finland: a 5-year retrospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-08)Background: Finland has the fourth highest injury mortality rate in the European Union. To better understand the causes of the high injury rate, and prevent these fatal injuries, studies are needed. Therefore, we set out to complete an analysis of the epidemiology of fatal trauma, and any contributory role for alcohol, long suspected to promote fatal injuries. As a study area, we chose the ... -
Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-23)Complement C5 inhibitor eculizumab treatment in atypical hemolytic uremic syndrome is effective, but associated with high costs. Complement inhibition monitoring in these patients has not been standardized. In this study we evaluated novel functional assays for application in routine follow-up. We documented that the Wieslab® complement screen assay showed a sensitivity of 1–2% of C5 activity ... -
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)Despite recent medical advances, atherosclerosis is a global burden accounting for numerous deaths and hospital admissions. Immune-mediated inflammation is a major component of the atherosclerotic process, but earlier research focus on adaptive immunity has gradually switched towards the role of innate immunity. The complement system and toll-like receptors (TLRs), and the crosstalk between them, ... -
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-13)Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was to evaluate whether or not the complement activity in newborns from pregnant women who receive eculizumab is impaired. A novel eculizumab-C5 complex (E-C5) specific assay was developed and ... -
Low immunoglobulin levels increase the risk of severe hypogammaglobulinemia in granulomatosis with polyangiitis patients receiving rituximab
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-06)Background: Randomized controlled trials and retrospective studies in ANCA-associated vasculitis (AAV) concurred that rituximab (RTX) is effective to induce and maintain remission. Infections and hypogammaglobulinemia during RTX were usually infrequent and uncomplicated. But in the Tromsø study cohort, 45 % of patients with granulomatosis with polyangiitis (GPA) developed hypogammaglobulinemia ... -
Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-29)Background: The role of prediabetes as a risk factor for hyperfiltration and albuminuria in persons who do not develop diabetes is unclear. The lack of evidence is mainly due to the difficulty of accurately assessing the glomerular filtration rate (GFR) in the near-normal range of GFR. We investigated whether prediabetes is an independent risk factor for glomerular hyperfiltration and high-normal ... -
Er det forskjell på subkutan og intravenøs tocilizumab ved behandling av revmatoid artritt?
(Journal article; Tidsskriftartikkel, 2015) -
Low CD4/CD8 ratio is associated with lower immunoglobulin levels in granulomatosis with polyangiitis patients receiving rituximab
(Journal article; Tidsskriftartikkel, 2014-09-03) -
Appendix E Telemedisinske løsninger i maritime operasjoner og redningstjeneste
(Research report; Forskningsrapport, 2016)Folk som jobber i maritime miljø har ikke enkel tilgang til sentrale helsetjenester, og det gjelder spesielt for sjøfolk som arbeider i arktiske områder. Selv om telemedisin har vært en suksess på land, har telemedisin kun i begrenset grad blitt tatt i bruk til havs. Dette skyldes blant annet fravær av gode kommunikasjonsløsninger, dårlige værforhold, store avstander og lange perioder utenfor ... -
Type 1 diabetes in Twitter: who all listen to?
(Peer reviewed; Chapter; Bokkapittel, 2015)Knowing what the conversation on Twitter regarding type 1 diabetes (T1D) is about can help in understanding the kind of information relevant to the individuals affected by the disease. The profile of Twitter users posting on T1D was collected and classified. The number of re-tweets was also registered. The tweets posted by non-governmental organizations (NGOs), communication media, and individuals ... -
Transfers to hospital in planned home birth in four Nordic countries – A prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)Introduction. Women planning for home birth are transferred to hospital in case of complications or elevated risk for adverse outcomes. The aim of the present study was to describe the indications for transfer to hospital in planned home births, and the proportion of cases in which this occurs. <p>Material and methods. Women in Norway, Sweden, Denmark and Iceland who had opted for, and were ... -
Combining autologous ventral hernia repair using component separation with DIEP breast reconstruction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-02)Concern about flap viability and abdominal wall integrity would normally exclude a patient with a large ventral midline hernia from having a breast reconstruction with a deep inferior epigastric perforator (DIEP) flap. Ventral hernia repair using the abdominoplasty approach has been reported before. The abdominoplasty flap would normally be discarded. This article presents a unique case of a ... -
Chronic nasal carriage of Staphylococcus aureus in granulomatosis with polyangiitis patients receiving rituximab maintenance: friend or foe?
(Journal article; Tidsskriftartikkel, 2014) -
Low CD4/CD8 ratio is associated with lower immunoglobulin levels in granulomatosis with polyangiitis patients receiving Rituximab
(Journal article; Tidsskriftartikkel, 2014) -
Risk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximab
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using ... -
Existing data sources in clinical epidemiology: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-16)Background: Although venous thromboembolism (VTE) is a known common complication in cancer patients, there is limited knowledge on patient-related and cancer-specific risk factors in the general population. The Scandinavian Thrombosis and Cancer (STAC) Cohort was established by merging individual data from three large Scandinavian cohorts (The Tromsø Study, the second Nord-Trøndelag Health Study, ... -
Automated analysis of color tissue Doppler velocity recordings of the fetal myocardium using a new algorithm
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-27)Background: Tissue Doppler imaging (TDI) can be used to assess fetal cardiac function and it has been shown to detect changes associated with hypoxia in animal models. However, the analysis is cumbersome and time consuming. The main objective of this study was to evaluate the feasibility of a new algorithm developed for the automated analysis of color TDI velocity recordings of the fetal myocardium. ...
