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norskInstitutt for klinisk medisin: Nye registreringer
Viser treff 1181-1200 av 1800
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Influence of a New “Call-Out Algorithm” for Management of Postoperative Pain and Its Side Effects on Length of Stay in Hospital: A Two-Centre Prospective Randomized Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-10)Background. We recently introduced the efficacy safety score (ESS) as a new “call-out algorithm” for management of postoperative pain and side effects. In this study, we report the influence of ESS recorded hourly during the first 8 hours after surgery on the mobility degree, postoperative nonsurgical complications, and length of hospital stay (LOS). Methods. We randomized 1152 surgical patients ... -
Preventing and treating medication overuse headache
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-01)The concept that headache treatment per se may be the cause of chronification of headache is not new,3 but our understanding of this concept, and the terminology defining it, have changed throughout the years. The criteria for MOH are based on expert consensus rather than formal evidence. According to the current definition in the latest (2013) International Classification of Headache Disorders–3 ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-23)<b>Background:</b> Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. The aim of this study was to investigate whether patients with comorbidity had inferior outcomes in a LD SCLC cohort. <br><b>Material and methods:</b> We analyzed patients ... -
High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted ... -
Negotiating the boundaries of psychosis: A qualitative study of the service provider perspective on treatment delay in community mental health
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-23)Aim: <br>Evidence shows that many patients are detected and treated late in their course of illness, and that substantial delay occurs even after entry to mental health services. Although several studies have examined the service user and carer perspectives on treatment delay, few have explored the issue from the service provider perspective. The aim of this study was to broaden our understanding ... -
Early versus late-applied constraint-induced movement therapy: A multisite, randomized controlled trial with a 12-month follow-up
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-07)Background and Purpose: <p> A direct comparison between the effects of constraint‐induced movement therapy (CIMT) applied early after stroke and that of CIMT applied in the chronic phase has not been conducted. This study aimed to compare the long‐term effects of CIMT applied 6 months after stroke with the results of CIMT applied within 28 days post‐stroke. <br>Methods: <p> This study was a ... -
Muscle mass and association to quality of life in non-small cell lung cancer patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-10)Background<br> Cancer wasting is characterized by muscle loss and may contribute to fatigue and poor quality of life (QoL). Our aim was to investigate associations between skeletal muscle index (SMI) and skeletal muscle radiodensity (SMD) and selected QoL outcomes in advanced non‐small cell lung cancer (NSCLC) at diagnosis.<p> Methods<br> Baseline data from patients with stage IIIB/IV NSCLC and ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood model was used as an inflammation predictor by measuring complement and leukocyte stimulation. Alginate microbeads were complement-compatible since they did not activate complement ... -
Psoriasis and associated variables in classification and outcome of juvenile idiopathic arthritis - an eight-year follow-up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-22)Background<br> To study the impact of psoriasis and features associated with psoriasis on classification and outcome in a population-based follow-up cohort of children with juvenile idiopathic arthritis (JIA).<p> Methods<br> In all, 440 children with JIA were followed for a median of 8 years in a prospective Nordic population-based cohort study. Data for remission was available for 427 of these ... -
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-01)Rationale:Antiphospholipid syndrome (APS) in pregnancy may trigger the lifethreatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement factor C5 is suggested as an additional treatment option.<p> Patient concerns, diagnosis and interventions: We present a pregnant patient treated with the C5-inhibitor eculizumab ... -
Human articular chondrocytes express functional Leukotriene B4 receptors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a potent chemoattractant associated with the development of osteoarthritis (OA), while its receptors BLT1 and BLT2 have been found in synovium and subchondral bone. In this study, we have investigated whether these receptors are also expressed by human cartilage cells and their potential effects on cartilage cells. The expression of LTB<sub>4</sub> ... -
Changes in the human transcriptome upon vitamin D supplementation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-19)Vitamin D is hydroxylated in the liver and kidneys to its active form, which can bind to the vitamin D receptor (VDR). The VDR is present in a wide variety of different cells types and tissues and acts as a transcription factor. Although activation of the VDR is estimated to regulate expression of up to 5% of the human genome, our study is the first analysing gene expression after supplementation ... -
Outcomes in pancreas transplantation with exocrine drainage through a duodenoduodenostomy versus duodenojejunostomy
(Journal article; Tidsskriftartikkel, 2017-08-23)Until recently, pancreas transplantation has mostly been performed with exocrine drainage via duodenojejunostomy (DJ). Since 2012, DJ was substituted with duodenoduodenostomy (DD) in our hospital, allowing endoscopic access for biopsies. This study assessed safety profiles with DD versus DJ procedures and clinical outcomes with the DD technique in pancreas transplantation. DD patients (n = 117; 62 ... -
Outpatient clinics treating substance use disorders in Northwest Russia and Northern Norway: a descriptive comparative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15)Both in Norway and Russia a considerable portion of the population have substance use disorders. However, the knowledge about outpatient services treating substance use disorders in Norway and Russia is limited. This study will describe and compare outpatient clinics treating substance use disorders in Arkhangelsk in Northwest Russia and in Bodø and Tromsø in Northern Norway on availability, ... -
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-19)The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007–2014) included 118 Norwegian female patients. All ... -
Impact of multi-professional, scenario-based training on postpartum hemorrhage in Tanzania: A quasi-experimental, pre- vs. post-intervention study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-05)Background: <br> Tanzania has a relatively high maternal mortality ratio of 410 per 100,000 live births. Severe postpartum hemorrhage (PPH) is a major cause of maternal deaths, but in most cases, it is preventable. However, most pregnant women that develop PPH, have no known risk factors. Therefore, preventive measures must be offered to all pregnant women. This study investigated the effects ... -
Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-24)Background: <br> Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce. <br> Objectives: <br> We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction. <br> Methods: <br> 228 patients were randomized 1:1 to receive ... -
Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditions and in response to androgens. In silico studies allowed the selection of 4 miRNAs ... -
Vitamin D and cognitive function: A Mendelian randomisation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. ... -
Do pre-hospital poisoning deaths differ from in-hospital deaths? A retrospective analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)Background: Most fatal poisonings occur outside the hospital and the victims found dead. The purpose of this study was to determine the general pattern and patient demographics of fatal poisonings in Northern Finland. In particular, we wanted to analyze differences between pre-hospital and in-hospital deaths.<p> Methods: All fatal poisonings that occurred in Northern Finland in 2007–2011 were ...
