Institutt for klinisk medisin: Nye registreringer

Viser treff 461-480 av 1800

    • Mammographic screening in Sami speaking municipalities and a control group. Are early outcome measures influenced by ethnicity? 

      Norum, Jan; Hofvind, Solveig; Nieder, Carsten; Schnell, Edrun Andrea; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-16)
      Objectives. Female citizens of Sami (the indigenous people of Norway) municipalities in northern Norway have a low risk of breast cancer. The objective of this study was to describe the attendance rate and outcome of the Norwegian Breast Cancer Screening Program (NBCSP) in the Sami-speaking municipalities and a control group.<p> <p>Study design. A retrospective registry-based study.<p> <p>Methods. ...

    • Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study 

      Synnestvedt, Marit; Borgen, Elin; Wist, Erik; Wiedswang, Gro; Weyde, Kjetil; Risberg, Terje; Kersten, Christian; Mjaaland, Ingvil; Vindi, Lise; Schirmer, Cecilie; Nesland, Jahn M; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-12-22)
      Background: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) after completion of systemic adjuvant treatment predicts reduced survival in breast cancer. The present study explores the use of DTCs to identify adjuvant insufficiently treated patients to be offered secondary adjuvant treatment intervention, and as a surrogate marker for therapy response.<p> <p>Methods: A total of ...

    • Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis 

      Graf, S; Lester, Susan; Nossent, Johannes C; Hill, C; Proudman, S. M; Lee, A; Rischmueller, Maureen (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-02-07)
      Introduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether ...

    • Geografiske ulikheter i tilbudet av polikliniske tjenester til barn og unge ved norske sykehus - et kulturperspektiv 

      Fundingsrud, Hans Petter; Lian, Olaug S (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-02)
      Nasjonale kartlegginger har påvist til dels store geografiske ulikheter i tilbudet av spesialisthelsetjenester til barn og unge i Norge. Tilbudsulikhetene varierer fra tre til fem ganger for enkelte sykdomskategorier. Disse ulikhetene kan ikke forklares med forskjeller i sykelighet. Helsepolitiske målsettinger om geografisk likeverdige tjenestetilbud til befolkningen tilsier at de geografiske ...

    • Perfusion dynamics in abdominal skin after free abdominal flap breast reconstruction using internal mammary vessels as recipient vessels. A clinical study using Dynamic Infrared Thermography 

      Nergård, Solveig; Mercer, James; de Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Background: Wound healing problems at the donor site in free abdominal flap breast reconstruction cause significant morbidity to patients. No studies have investigated what impact the use of the internal mammary artery in free abdominal flap breast reconstruction has on abdominal skin perfusion. We hypothesized that harvesting the internal mammary vessels (IMV) has a negative effect on abdominal ...

    • Effectiveness of surgery for sciatica with disc herniation is not substantially affected by differences in surgical incidences among three countries: results from the Danish, Swedish and Norwegian spine registries 

      Lagerbäck, Tobias; Fritzell, Peter; Hägg, Olle; Nordvall, Dennis; Lønne, Greger; Solberg, Tore; Andersen, Mikkel Ø.; Eiskjær, Søren; Gehrchen, Martin; Jacobs, Wilco C.; van Hooff, Miranda L.; Gerdhem, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-29)
      Purpose Yearly incidence of surgery for symptomatic lumbar disc herniation varies and is 29/100,000 in Sweden, 46/100,000 in Denmark and 58/100,000 in Norway. This variation was used to study whether diferences in surgical incidence were associated with diferences in preoperative patient characteristics as well as patient-reported outcomes.<p> Methods Data from the national spine registers in ...

    • Alcohol consumption and common carotid intima-media thickness: The USE-IMT study 

      Britton, Annie R.; Grobbee, Diederick E.; den Ruijter, Hester M.; Anderson, Todd J.; Desvarieux, Moise; Engström, Gunnar; Evans, Greg W.; Hedblad, Bo; Kauhanen, Jussi; Kurl, Sudhir; Lonn, Eva M.; Mathiesen, Ellisiv B.; Polak, Joseph F.; Price, Jacqueline F.; Rembold, Christopher M.; Rosvall, Maria; Rundek, Tatjana; Salonen, Jukka T.; Stehouwer, Coen; Tuomainen, Tomi-Pekka; Bots, Michiel L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-19)

    • Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

      Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-15)
      Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation from carnitine is via the microbiota-dependent intermediate g-butyrobetaine (gBB). Elevated TMAO levels are associated with cardiovascular disease (CVD), but little ...

    • Opportunities and Challenges of a Rural-telemedicine Program in Nepal 

      Bhatta, Ramesh; Aryal, Kabita; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015)
      Background:Telemedicine services are considered essential for improving the accessibility, quality and efficiency of the healthcare services in developing countries. With these expectations, government of Nepal has implemented a rural-telemedicine program in thirty peripheral district hospitals to improve the accessibility of specialist health services. Telemedicine can be appropriate to the ...

    • User Feedback on the MSF Tele-Expertise Service After a 4-Year Pilot Trial – A Comprehensive Analysis 

      Bonnardot, Laurent; Wootton, Elizabeth; Liu, Joanne; Steichen, Olivier; Bradol, Jean-Hervé; Hervé, Christian; Wootton, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11-20)
      We surveyed all users of the Médecins Sans Frontières (MSF) tele-expertise service, approximately four years after it began operation. The survey contained 50 questions and was sent to 294 referrers and 254 specialists. There were 163 responses (response rate 30%). There were no significant differences between the responses from French and English users, so the responses were combined for ...

    • Ventilasjon av operasjonsstuer: forenklet metodevurdering 

      Risstad, Hilde; Holtet Evensen, Line; Movik, Espen; Lerner, Martin Robert (Research report; Forskningsrapport, 2022)
      Postoperative sårinfeksjoner fører til økt sykelighet og dødelighet. Ventilasjonssystem i operasjonsstuer er én av mange faktorer som kan påvirke infeksjonsforekomst. Hvilket ventilasjonssystem som er best på å forebygge infeksjoner i operasjonssår har vært diskutert i mange år.<p> <p>Vi har utarbeidet en forenklet metodevurdering for å undersøke effekten av laminær ventilasjon (LAF) på infeksjonsforekomst. ...

    • Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs 

      Ben-Batalla, Isabel; Cubas-Cordova, Miguel; Udonta, Florian; Wroblewski, Mark; Waizenegger, Jonas S.; Janning, Melanie; Sawall, Stefanie; Gensch, Victoria; Zhao, Lin; Martinez, Inigo Zubiavrre; Riecken, Kristoffer; Fehse, Boris; Pantel, Klaus; Bokemeyer, Carsten; Loges, Sonja (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)
      Anti-angiogenic therapies were approved for different cancers. However, significant primary and secondary resistance hampers efficacy in several tumor types including breast cancer. Thus, we need to develop clinically applicable strategies to enhance efficacy of anti-angiogenic drugs. We report that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product ...

    • Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Zachariadis, Vasilios; Cavelier, Lucia; Dahlberg, Johan; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Overnäs, Elin; Abrahamsson, Jonas; Flægstad, Trond; Heyman, Mats M.; Jónsson, Ólafur G.; Kanerva, Jukka; Larsson, Rolf; Palle, Josefine; Schmiegelow, Kjeld; Gustafsson, Mats G.; Lönnerholm, Gudmar; Forestier, Erik; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)
      Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ...

    • The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas 

      Søland, Tine Merete; Solhaug, Maren Bråten; Bjerkli, Inger-Heidi; Schreurs, Olaf Joseph Franciscus; Sapkota, Dipak (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. ...

    • Comorbidity in multiple sclerosis patients from Nordland County, Norway - validated data from the Norwegian Patient Registry 

      Benjaminsen, Espen; Myhr, Kjell-Morten; Torkildsen, Nina Agnethe Grytten; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-16)
      <p><i>Background:</i> Knowledge of comorbid disorders is important to optimize therapy for multiple sclerosis (MS), but data are limited. The aim of this study was to assess comorbidity in persons with MS living in Nordland County on January 1, 2017. <p><i>Methods:</i> Data were retrieved from the Norwegian Patient Registry (2008-2017) and validated through review of electronic hospital charts ...

    • Delivery Room ST Segment Analysis to Predict Short Term Outcomes in Near-Term and Term Newborns 

      Linde, Jørgen Erland; Solevåg, Anne Lee; Eilevstjønn, Joar; Blacy, Ladislaus; Kidanto, Hussein; Ersdal, Hege Langli; Klingenberg, Claus Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-03)
      Background: ST-segment changes to the fetal electrocardiogram (ECG) may indicate fetal acidosis. No large-scale characterization of ECG morphology immediately after birth has been performed, but ECG is used for heart rate (HR) assessment. We aimed to investigate ECG morphology immediately after birth in asphyxiated infants, using one-lead dry-electrode ECG developed for HR measurement. Methods: ...

    • Drawing on the doctor-patient relationship in e-health services 

      Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      The doctor-patient relationship has been the cornerstone of medical practice. As e-health is coming to play an increasingly important role, it is necessary to consider how e-health can draw on, integrate and safeguard aspects of this relationship and thereby improve services and engage patients.

    • Drug-Eluting versus Bare-Metal Stents in Saphenous Vein Grafts Compared to Native Coronary Vessels: The Norwegian Coronary Stent Trial Study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Rotevatn, Svein; Mannsverk, Jan Torbjørn; Larsen, Tommy; Larsby, Kristina; Skarstad, Sigrun; Fosse, Eivind Øygard; Dahl-Eriksen, Øystein; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)
      Background: Drug-eluting stents (DES) reduce target lesion revascularization (TLR) with no effect on mortality or myocardial infarction (MI) compared to bare-metal stents (BMS) in native vessels. Randomized stent studies in saphenous vein grafts (SVG) are few and the reported effects are ambiguous. The Norwegian Coronary Stent Trial study is the first to randomize lesions to percutaneous coronary ...

    • Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies 

      Solmi, Marco; Fiedorowicz, Jess; Poddighe, Laura; Delogu, Marco; Høye, Anne; Miola, Alessandro; Heiberg, Ina Heidi; Stubbs, Brendon; Smith, Lee; Larsson, Henrik; Attar, Rubina; Nielsen, René E; Cortese, Samuele; Shin, Jae Il; Firth, Joseph; Fusar-Poli, Paolo; Yatham, Lakshmi N; Carvalho, Andre F; Castle, David J; Correll, Christoph U; Seeman, Mary V (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-14)
      <p><i>Objective:</i> This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. <p><i>Methods:</i> The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and ...

    • Assessment of extracranial metastatic disease in patients with brain metastases: How much effort is needed in the context of evolving survival prediction models? 

      Nieder, Carsten; Mehta, Minesh P.; Guckenberger, Matthias; Gaspar, Laurie E.; Rusthoven, Chad G.; Sahgal, Arjun; Grosu, Anca L.; De Ruysscher, Dirk (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)
      Survival prediction models may serve as decision-support tools for clinicians who have to assign the right treatment to each patient, in a manner whereby harmful over- or undertreatment is avoided as much as possible. Current models differ regarding their components, the overall number of components and the weighting of individual components. Some of the components are easy to assess, such as age ...