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norskInstitutt for klinisk medisin: Nye registreringer
Viser treff 1321-1340 av 1801
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D-Dimer Measured At First Venous Thromboembolism Is Associated With Future Risk Of Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12)D-dimer >5000 ng/ml at incident VTE is associated with a higher risk of subsequent cancer within one and two years. High D-dimer levels are also associated with more aggressive tumor biology and poor prognosis in these patients. As D-dimer is routinely measured in the assessment of suspected VTE, it may be a useful surrogate marker for the presence of an underlying malignancy. Our findings may suggest ... -
Multisite musculoskeletal pain in adolescence and later mental health disorders: a population-based registry study of Norwegian youth: the NAAHS cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-01)<b>Objectives:</b> To examine the association between multisite musculoskeletal pain in adolescence and mental health disorders in young adulthood. <br><b>Design and setting: </b>Data were obtained from a linkage between the Norwegian Patient Registry (2008 – 2012) and the Norwegian Arctic Adolescent Health Study, a school-based survey conducted among 10th grade students in North Norway (2003 – ... -
The relationship between pain and perceived stress in a population-based sample of adolescents – Is the relationship gender specific?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-01)In the current issue of the Scandinavian Journal of Pain, Berit Østerås, Hermundur Sigmundsson and Monika Haga investigates for potential gender differences in the relationship between pain and perceived stress in adolescents, and present interesting findings [1]. Females, both adolescent and adults, report more pain, psychosocial problems and mental health problems than males. On that note some ... -
The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-24)Background Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post-PHx, utilizing an analytical platform more sensitive and precise than earlier ... -
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF
(Journal article; Tidsskriftartikkel, 2014-07-05)Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activation is recognized as necessary for the recruitment of inflammatory cells to the ... -
CHRONIC NASAL CARRIAGE OF STAPHYLOCOCCUS AUREUS DOES NOT INCREASE THE RISK OF RELAPSE AND SEVERE INFECTIONS IN GRANULOMATOSIS WITH POLYANGIITIS PATIENTS WHEN RECEIVING RITUXIMAB MAINTENANCE TREATMENT
(Conference object; Konferansebidrag, 2014-06-10) -
Fibroblast miR-210 overexpression is independently associated with clinical failure in Prostate Cancer – a multicenter (in situ hybridization) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-08)There is a need for better prognostication in prostate cancer (PC). “The micromanager of hypoxia”, microRNA-210 (miR-210) is directly linked to hypoxia, is overexpressed in PC and has been implied in tumor cell-fibroblast crosstalk. We investigated the prognostic impact of miR-210 in tumor cells and fibroblasts in PC. Tumor and stromal samples from a multicenter PC cohort of 535 prostatectomy patients ... -
What are diabetes patients discussing on social media?
(Conference object; Konferansebidrag, 2016-11-15)Social media channels are being used more and more by people with diabetes for exchanging health information, experiences with their chronic condition, and asking and giving advice to their peers[1]. The objective of this study is to describe the nature of the information that is shared on Norwegian diabetes social media groups, and the users’ reactions to these posts. -
Evaluation of a trauma team activation protocol revision: A prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-25)<b>Background:</b> Correct triage based on prehospital information contributes to a better outcome for potentially seriously injured patients. In 2011 we changed the trauma team activation (TTA) criteria in our center in order to improve the high over- and undertriage properties of the protocol. Five criteria that were unable to predict severe injury were removed. In the present study, we evaluated ... -
Weight Change and Risk of Venous Thromboembolism: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-20)<b>Background:</b> Obesity is a major risk factor for venous thromboembolism (VTE), but it is unknown to what extent weight change over time affects VTE risk.<br> <b>Aims:</b> To investigate the association between weight change and risk of incident VTE in a population-based cohort with repeated measurements.<br> <b>Methods:</b> Participant data were collected from the Tromsø 3 (1986–87), 4 ... -
Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)<i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ... -
Altered pharmacological effects of adrenergic agonists during hypothermia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ... -
Autologous chondrocyte implantation for hip osteochondritis functioning 15 years after operation
(Journal article; Tidsskriftartikkel, 2016-11-30)<b>Background:</b> The autologous implantation technique (ACI) was first introduced in studies on cartilage defects in knees. It has later been used for the treatment of osteochondral knee lesions. The patient presented here had a hip osteochondral defect measuring 4 cm in diameter. He was a candidate for hip prosthesis because of serious pain and reduced function. Being young and highly motivated ... -
Women with coronary heart disease – making sense of their symptoms and their experiences from interacting with their general practitioners
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-01)Cardiovascular disease and particularly coronary heart disease (CHD) is the leading cause of death among women and men worldwide. CHD in women, and their symptoms and treatment trajectory are not well understood. Studies indicate gender-related differences in symptom presentation, comorbidity, help-seeking behavior, and the quality of diagnostics and treatment of CHD. Although the incidence ... -
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-16)The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere types; alginate microbeads, liquefied core poly-l-ornithine (PLO)-containing microcapsules, liquefied core poly-l-lysine (PLL)-containing microcapsules, and solid core PLL-containing ... -
Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-23)<b>Purpose:</b> Glucosamine (GlcN) supplements are promoted for medical reasons, for example, for patients with arthritis and other joint-related diseases. Oral intake of GlcN is followed by uptake in the intestine, transport in the circulation and thereafter delivery to chondrocytes. Here, it is postulated to have an effect on synthesis and turnover of extracellular matrix constituents expressed ... -
Internet-based provider-patient communication in Ghana: recent findings
(Conference object; Konferansebidrag, 2016-11-15)While most people in the West have had easy access to the Internet for some time [1], with the dissemination of smart phones with Internet access this is now also rapidly becoming the case in West Africa [2]. Until recently, provider-patient communication has typically taken the form of face-toface interactions or telephone calls [3]. In Africa, the Internet and especially the social media are ... -
N-Acetyl-β-D-Glucosaminidase Does Not Enhance Prediction of Cardiovascular or All-Cause Mortality by Albuminuria in a Low-Risk Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-05)Albuminuria is a well known risk factor for cardiovascular disease and mortality, but focus on renal tubular dysfunction as a potential risk factor is growing also. The association between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and cardiovascular risk has been assessed mostly in cross-sectional studies. We studied the cross-sectional associations between urinary NAG and cardiovascular ... -
Ischemic Stroke and Risk of Venous Thromboembolism in the General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-07)<i>Background</i> - Even though clinical data support a relation between ischemic stroke and venous thromboembolism (VTE), the strength and time dependence of the association remain to be settled at the population level. We therefore aimed to investigate the association between ischemic stroke and VTE in a prospective population-based cohort.<p> <p><i>Methods and Results</i> - Participants (n=30 ... -
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-10)<p><i>Background - </i>Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition ...
