Institutt for klinisk medisin: Nye registreringer

Viser treff 141-160 av 1800

    • C-reactive protein levels and depression in older and younger adults - A study of 19,947 individuals. The Tromsø study 

      Bugge, Erlend; Wynn, Rolf; Mollnes, Tom Eirik; Reitan, Solveig Merete Klæbo; Lapid, Maria I.; Grønli, Ole Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-17)
      In recent years, a connection between depression and inflammation has been established, with a range of immunological changes, both cellular and humoral, presenting during depressive states (Beydoun et al., 2016; Haapakoski et al., 2015; Wium-Andersen et al., 2013). Furthermore, there seems to be a dose-response relationship between depression and inflammation, in the sense that the more severe the ...

    • Percent of remaining life on palliative radiation treatment: solely a function of fractionation? 

      Nieder, Carsten; Mannsåker, Bård; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-14)
      Background: This study analyzed the percent of remaining life (PRL) on treatment in patients irradiated for bone metastases. Bone metastases were treated together with other target volumes, if indicated, e.g. a 10-fraction treatment course that included brain and bone metastases. PRL was determined by calculating the time between start and finish of palliative radiotherapy (minimum 1 day in case of ...

    • Inflammatory Biomarkers Can Differentiate Acute Lymphoblastic Leukemia with Arthropathy from Juvenile Idiopathic Arthritis Better Than Standard Blood Tests 

      Brix, Ninna; Glerup, Mia; Foell, Dirk; Kessel, Christoph; Wittkowski, Helmut; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Herlin, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-04)
      Objective - To evaluate the predictive value of biomarkers of inflammation like phagocyte-related S100 proteins and a panel of inflammatory cytokines in order to differentiate the child with acute lymphoblastic leukemia (ALL) from juvenile idiopathic arthritis (JIA).<p> <p>Study design - In this cross-sectional study, we measured S100A9, S100A12, and 14 cytokines in serum from children with ALL ...

    • Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study 

      Beqiri, Erta; Smielewski, Peter; Guérin, Claude; Czosnyka, Marek; Robba, Chiara; Bjertnæs, Lars Jakob; K Frisvold, Shirin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)
      Introduction - Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.<p> <p>Methods ...

    • Cohesive collisions of particles in liquid media studied by CFD-DEM, video tracking, and Positron Emission Particle Tracking 

      Saparbayeva, Nazerke; Chang, Yu-Fen; Kosinski, Pawel Jan; hoffmann, alex christian; Balakin, Boris; Struchalin, Pavel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      This paper investigates the cohesive collision of ice in an oil phase at temperatures ranging from −15.7 °C to −0.3 °C. The new information on the coefficient of restitution (COR) was obtained using three different velocity measurement methods: high-speed experimental video recording, Positron Emission Particle Tracking (PEPT), and numerical simulations. A new type of PEPT tracer was developed for ...

    • Reflections on measuring disordered thoughts as expressed via language 

      Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)
      Thought disorder, as inferred from disorganized and incoherent speech, is an important part of the clinical presentation in schizophrenia. Traditional measurement approaches essentially count occurrences of certain speech events which may have restricted their usefulness. Applying speech technologies in assessment can help automate traditional clinical rating tasks and thereby complement the ...

    • Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure 

      Nendl, Andraz; Raju, Sajan; Broch, Kaspar; Mayerhofer, Christiane Caroline; Holm, Kristian; Halvorsen, Bente; Lappegård, Knut Tore; Moscavitch, Samuel; Hov, Johannes Espolin Roksund; Seljeflot, Ingebjørg; Trøseid, Marius; Awoyemi, Ayodeji Olawale (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-02)
      Background: The gut microbiota in patients with chronic heart failure (HF) is characterized by low bacterial diversity and reduced ability to synthesize beneficial metabolites. These changes may facilitate leakage of whole bacteria or bacterial products from the gut into the bloodstream, which may activate the innate immune system and contribute to the low-grade inflammation seen in HF. In this ...

    • Optimized workflow to modify microRNA expression in primary human intravascular cells 

      Caglayan, Safak; Hansen, John Bjarne; Snir, Omri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)
      Background - A comprehensive dissection of the role of microRNAs (miRNAs) in gene regulation and subsequent cell functions requires a specific and efficient knockdown or overexpression of the miRNA of interest; these are achieved by transfecting the cell of interest with a miRNA inhibitor or a miRNA mimic, respectively. Inhibitors and mimics of miRNAs with a unique chemistry and/or structural ...

    • The effect of selective ultrasound screening on the incidence of late presentation of developmental hip dysplasia—a meta-analysis 

      Laborie, Lene Bjerke; Rosendahl, Karen; Dhouib, Amira; Simoni, Paolo; Tomà, Paolo; Offiah, Amaka C (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      Different screening strategies for developmental dysplasia of the hip (DDH) exist. Despite screening efforts, cases of late presentation continue to occur, often necessitating surgery. This systematic review and meta-analysis assess the effect of newborn selective ultrasound screening for DDH on the incidence of late presentation in infants and children, compared to a universal ultrasound strategy. ...

    • The Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Study 

      Sahakyan, Mushegh; Kleive, Dyre; Dille-Amdam, Rachel G.; Kjeseth, Trond; Waardal, Kim; Edwin, Bjørn von Gohren; Nymo, Linn Såve; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)
      Background and purpose Preoperative infammatory markers, such as Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio, were shown to be associated with prognosis in patients undergoing pancreatectomy for cancer. However, little is known about their predictive role in a Western population.<p> <p>Methods The Norwegian National Registry for Gastrointestinal ...

    • Continuous positive airway pressure in cluster headache: A randomized, placebo-controlled, triple-blind, crossover study 

      Gravdahl, Gøril Bruvik; Aakerøy, Lars; Stovner, Lars Jacob; Engstrøm, Morten; Müller, Kai Ivar; Bjørk, Marte-Helene; Tronvik, Erling Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-09)
      Background - Oxygen inhalation aborts cluster headache attacks, and case reports show the effect of continuous positive airway pressure. The aim of this study was to investigate the prophylactic effect of continuous positive airway pressure in chronic cluster headache.<p> <p>Methods - This was a randomized placebo-controlled triple-blind crossover study using active and sham continuous positive ...

    • Association of physical activity with overall mortality among long-term testicular cancer survivors: A longitudinal study 

      Thorsen, Lene; Courneya, Kerry S.; Steene-Johannessen, Jostein; Gran, Jon Michael; Haugnes, Hege Sagstuen; Negaard, Helene Francisca Stigter; Kiserud, Cecilie E.; Fosså, Sophie Dorothea (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-19)
      Physical activity (PA) has been associated with reduced mortality among cancer survivors, but no study has focused on testicular cancer survivors (TCSs). We aimed to investigate the association of PA measured twice during survivorship with overall mortality in TCSs. TCSs treated during 1980 to 1994 participated in a nationwide longitudinal survey between 1998 to 2002 (S1: n = 1392) and 2007 to 2009 ...

    • Opposite and dynamic regulation of the interferon response in metastatic and non-metastatic breast cancer 

      Lamsal, Apsana; Andersen, Sonja Benedikte; Johansson, Ida; Vietri, Marina; Bokil, Ansooya Avinash; Kurganovs, Natalie Jayne; Rylander, Felicia; Bjørkøy, Geir; Pettersen, Kristine; Giambelluca, Miriam Soledad (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      Background To our current understanding, solid tumors depend on suppressed local immune reactions, often elicited by the interaction between tumor cells and tumor microenvironment (TME) components. Despite an improved understanding of anti-cancer immune responses in the TME, it is still unclear how immuno-suppressive TME are formed and how some cancer cells survive and metastasize.<p> <p>Methods ...

    • Prompt closure versus gradual weaning of external ventricular drainage for hydrocephalus following aneurysmal subarachnoid haemorrhage: Protocol for the DRAIN randomised clinical trial 

      Capion, Tenna; Lilja-Cyron, Alexander; Olsen, Markus Harboe; Juhler, Marianne; Moeller, Kirsten; Sorteberg, Angelika; Rønning, Pål Andre; Poulsen, Frantz Rom; Wismann, Joakim; Ravlo, Celina; Isaksen, Jørgen Gjernes; Lindschou, Jane; Gluud, Christian; Mathiesen, Tiit (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a life-threatening disease caused by rupture of an intracranial aneurysm. A common complication following aSAH is hydrocephalus, for which placement of an external ventricular drain (EVD) is an important first-line treatment. Once the patient is clinically stable, the EVD is either removed or replaced by a ventriculoperitoneal shunt. The ...

    • Hand grip strength in venous thromboembolism: risk of recurrence and mortality 

      Leknessund, Oda; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ...

    • Radiographic markers of hip dysplasia in young adults: predictive effect of factors in early life 

      Laborie, Lene Bjerke; Lie, Stein Atle; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-11)
      Background and objectives Acetabular dysplasia in young adults occurs, despite screening for developmental hip dysplasia (DDH) in the neonatal period. We aimed to examine how early life factors predict radiographic measurements of acetabular dysplasia at 18–19 years of age.<p> <p>Methods From a previous randomized trial (n=12,014; 1988–90) evaluating the role of hip ultrasound in newborn screening ...

    • The acceptability of implementing patient-reported measures in routine maternity care: A systematic review 

      Chen, An; Väyrynen, Kirsi; Leskelä, Riikka-Leena; Torkki, Paulus; Heinonen, Seppo; Tekay, Aydin; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-16)
      Introduction - Patient-reported measures (PRMs) are becoming popular as they might influence clinical decisions, help to deliver patient-centered care, and improve health care quality. However, the limited knowledge and consensus about the acceptability of implementing PRMs in maternity care hinder their widespread use in clinical practice, and evidence-based recommendations are lacking. This ...

    • Validation of a prediction model for post-chemotherapy fibrosis in nonseminoma patients 

      Gerdtsson, Axel; Torisson, Gustav; Thor, Anna; Grenabo Bergdahl, Anna; Almås, Bjarte; Håkansson, Ulf; Törnblom, Magnus; Negaard, Helene Francisca Stigter; Glimelius, Ingrid; Halvorsen, Dag; Karlsdottir, Åsa; Haugnes, Hege Sagstuen; Larsen, Signe Melsen; Holmberg, Göran; Wahlqvist, Rolf; Tandstad, Torgrim; Cohn-Cedermark, Gabriella; Ståhl, Olof; Kjellman, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-02)
      Objective - To validate Vergouwe's prediction model using the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) RETROP database and to define its clinical utility.<p> <p>Materials and methods - Vergouwe's prediction model for benign histopathology in post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) uses the following variables: presence of teratoma in orchiectomy specimen; ...

    • Close to zero preventable in-hospital deaths in pediatric trauma patients – An observational study from a major Scandinavian trauma center 

      Ringen, Amund Hovengen; Baksaas-Aasen, Kjersti; Skaga, Nils Oddvar; Wisborg, Torben; Gaarder, Aslaug Christine; Næss, Pål Aksel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-30)
      Background: In line with international trends, initial treatment of trauma patients has changed substantially over the last two decades. Although trauma is the leading cause of death and disability in children globally, in-hospital pediatric trauma related mortality is expected to be low in a mature trauma system. To evaluate the performance of a major Scandinavian trauma center we assessed treatment ...

    • The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol 

      Bramness, Jørgen Gustav; Skulberg, Knut Ragnvald; Skulberg, Andreas; Moe, Jenny Skumsnes; Mørland, Jørg Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-28)
      Aims - A high number of alcohol units required to feel a subjective effect of alcohol predicts future alcohol use disorders (AUDs). The subjective response to alcohol can be measured using the validated retrospective self-rated effects of alcohol (SRE) questionnaire. Few studies have investigated the specific relationship between SRE and blood alcohol concentration (BAC) in an experimental ...