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dc.contributor.authorAlakunle, Emmanuel
dc.contributor.authorKolawole, Daniel
dc.contributor.authorDiaz Cánova, Diana Karina
dc.contributor.authorAlele, Faith
dc.contributor.authorAdegboye, Oyelola
dc.contributor.authorMoens, Ugo
dc.contributor.authorOkeke, malachy ifeanyi
dc.date.accessioned2024-09-17T07:11:34Z
dc.date.available2024-09-17T07:11:34Z
dc.date.issued2024-03-06
dc.description.abstractMonkeypox virus (MPXV) is the etiological agent of monkeypox (mpox), a zoonotic disease. MPXV is endemic in the forested regions of West and Central Africa, but the virus has recently spread globally, causing outbreaks in multiple non-endemic countries. In this paper, we review the characteristics of the virus, including its ecology, genomics, infection biology, and evolution. We estimate by phylogenomic molecular clock that the B.1 lineage responsible for the 2022 mpox outbreaks has been in circulation since 2016. We interrogate the host-virus interactions that modulate the virus infection biology, signal transduction, pathogenesis, and host immune responses. We highlight the changing pathophysiology and epidemiology of MPXV and summarize recent advances in the prevention and treatment of mpox. In addition, this review identifies knowledge gaps with respect to the virus and the disease, suggests future research directions to address the knowledge gaps, and proposes a One Health approach as an effective strategy to prevent current and future epidemics of mpox.en_US
dc.identifier.citationAlakunle, Kolawole, Diaz Cánova, Alele, Adegboye, Moens, Okeke. A comprehensive review of monkeypox virus and mpox characteristics. Frontiers in Cellular and Infection Microbiology. 2024;14en_US
dc.identifier.cristinIDFRIDAID 2259707
dc.identifier.doi10.3389/fcimb.2024.1360586
dc.identifier.issn2235-2988
dc.identifier.urihttps://hdl.handle.net/10037/34737
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Cellular and Infection Microbiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleA comprehensive review of monkeypox virus and mpox characteristicsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)