Acquisition of peak bone mass in a Norwegian youth cohort : longitudinal findings from the Fit Futures study 2010–2022
Permanent lenke
https://hdl.handle.net/10037/35420Dato
2024-07-03Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Sagelv, Edvard Hamnvik; Emaus, Nina Alice; Evensen, Elin Kristin; Christoffersen, Tore; Dennison, Elaine; Furberg, Anne-Sofie; Grimnes, Guri; Johansson, Jonas Lars; Nielsen, Christopher Sivert; Nilsen, Ole Andreas; Winther, AnneSammendrag
Purpose To examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.
Method In a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16–19 years into adulthood (age of 26–29) on three occasions: 2010–2011 (Fit Futures 1 (FF1)), 2012–2013 (FF2), and 2021–2022 (FF3), measuring BMD (g/cm2 ) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.
Results From the median age of 16 years (FF1), femoral neck BMD (mean g/cm2 (95% CI)) slightly increased in females from 1.070 (1.059–1.082) to 1.076 (1.065–1.088, p=0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029–1.053, p<0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091–1.116); 27 years, 1.063 (1.050–1.077, p<0.001); and for the total hip in both sexes (both p<0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133–1.148); 27 years, 1.204 (1.196–1.212), p<0.001; males: 16 years, 1.179 (1.170–1.188); 27 years, 1.310 (1.296–1.315), p<0.001).
Conclusion BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.