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norskDet helsevitenskapelige fakultet: Recent submissions
Now showing items 2041-2060 of 10412
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Composite immune marker scores associated with severe mental disorders and illness course
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-02)Background: Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation and clinical characteristics is suggested. However, few studies have investigated how patterns across immune markers are related to diagnosis and illness course.<p > <p>Methods: A total of 948 participants with a diagnosis of schizophrenia (SCZ, N ... -
Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010–2019
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)Aims: This study aimed to analyse results on early screening outcomes, including recall and cancer rates, and histopathological tumour characteristics among non-immigrants and immigrants invited to BreastScreen Norway. Methods: We included information about 2, 763,230 invitations and 2,087,222 screening examinations from 805,543 women aged 50–69 years who were invited to BreastScreen Norway between ... -
Chemical and Enzyme-Assisted Extraction of Fucoidan from two Species of Brown Macroalgae (Ascophyllum nodosum and Saccharina latissima)
(Conference object; Konferansebidrag, 2022)Macroalgae are vital species and are known to produce a wide range of bioactive compounds including polysaccharides, such as fucoidan. Traditionally, these compounds are extracted using hazardous solvents that leads to environmental pollution and waste. Considering this, more sustainable technologies are being investigated as greener alternatives.<p> <p>The main goal of this study was to ... -
Digital hjemmeoppfølging og ressursbruk i primær- og spesialisthelsetjenesten: en systematisk oversikt
(Research report; Forskningsrapport, 2022-04)Velferdsteknologi, inkludert digital hjemmeoppfølging, er et viktig element i utviklingen av helse- og omsorgssektoren. Formålet med denne systematiske oversikten var å undersøke effekter av digital hjemmeoppfølging for voksne med ikke-smittsomme kroniske sykdommer mht. ressursbruk i primær- og spesialisthelsetjenesten. Digital hjemmeoppfølging i denne oversikten innebærer forhåndsavtalte helserelaterte ... -
Predictors of extubation success: a population-based study of neonates below a gestational age of 26 weeks
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)Objective The aim of the study was to investigate first extubation attempts among extremely premature (EP) infants and to explore factors that may increase the quality of clinical judgement of extubation readiness. Design and method A population-based study was conducted to explore first extubation attempts for EP infants born before a gestational age (GA) of 26 weeks in Norway between 1 January ... -
High expression of miR-17-5p and miR-20a-5p predicts favorable disease-specific survival in stage I-III colon cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)In many types of cancer, microRNAs (miRs) are aberrantly expressed. The aim of this study was to explore the prognostic impact of miR-17-5p and miR-20a-5p in colon cancer. Tumor tissue from 452 stage I-III colon cancer patients was retrospectively collected and tissue microarrays constructed. miR-17-5p and miR-20a-5p expression was evaluated by in situ hybridization and analyzed using digital ... -
Longitudinal changes in concentrations of persistent organic pollutants (1986–2016) and their associations with type 2 diabetes mellitus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)Background: Positive associations have been reported between persistent organic pollutants (POPs) and type 2 diabetes mellitus (T2DM); however, causality has not been established. Over the last decades, environmental exposure to legacy POPs has decreased, complicating epidemiological studies. In addition, physiological risk factors for T2DM may also influence POP concentrations, contributing to ... -
Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-27)To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established ... -
Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-15)Background: Ways to prevent disease-induced vascular modifcations that accelerate brain damage remain largely elusive. Improved understanding of perivascular cell signalling could provide unparalleled insight as these cells impact vascular stability and functionality of the neurovascular unit as a whole. Identifying key drivers of astrocyte and pericyte responses that modify cell–cell interactions ... -
Foreldre til barn med Downs Syndrom – en spørreundersøkelse om deres møte med helsevesenet
(Master thesis; Mastergradsoppgave, 2020-08-31)Bakgrunn: Årlig fødes ca 70-80 barn med Downs syndrom (DS) i Norge. Disse har en økt prevalens av komorbiditeter, og som følge av dette et økt behov for oppfølging i helsevesenet. Flere land har utviklet anbefalinger for hva som bør følges opp hos individer med DS. Hypotesen bak oppgaven er at barn med DS ikke følges tilstrekkelig opp i norsk helsevesen. Årsaker til dette kan være både knyttet til ... -
Metabolomics in neonatal sepsis
(Master thesis; Mastergradsoppgave, 2020-08-31)<p>BACKGROUND: The clinical signs of neonatal sepsis are nonspecific and therefore antibiotic treatment is often initiated in clinically suspected cases. This approach causes concern in regard to possible overuse of antibiotics in newborns. Metabolomics is an emerging field of focus for neonatologists due to its potential phenotypical insight into cellular and metabolic processes, contributing to ... -
Multisite musculoskeletal pain, self-harm and suicidal behaviour in Northern Norwegian adolescents: a population-based study
(Master thesis; Mastergradsoppgave, 2020-08-31)<p><i>Background:</i> Self-harm and suicidal behaviour commonly debuts and increases during adolescence. Suicidal behaviour is a major public health concern and is associated with later suicidal behaviour, mental health disorders and poor functioning in adulthood. Musculoskeletal pain also increases during adolescence and multisite pain is associated with increased disability and psychosocial problems. ... -
The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were ... -
"Oppfølging av eldre med depresjon er ikke en prioritert sykepleieoppgave" En kvalitativ studie om hjemmesykepleiere sine erfaringer med oppfølging av eldre med depresjon
(Mastergradsoppgave; Master thesis, 2020-09-03)Bakgrunn: I denne undersøkelsen søkes det innsikt i erfaringer hjemmesykepleiere har med oppfølging av eldre med depresjon. Flere lovpålagte oppgaver, begrensede ressurser og flere pasienter med behov for pleie- og omsorgstjenester har vært med å legge et press om mer effektivitet i hjemmesykepleien. Eldre utgjør en stor del av pasientgrunnlaget for denne tjenesten. Forskning viser at depresjon er ... -
Sykepleieres erfaringer med sepsispasienter i en distrikslegevakt.
(Mastergradsoppgave; Master thesis, 2020-09-03)Sykepleieres erfaringer med sepsispasienter i en distrikslegevakt. En kvalitativ studie med fokusgruppeintervju -
Risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) among women with HPV-test in 1990-1992
(Master thesis; Mastergradsoppgave, 2020-08-30)Background/objective: Long-term follow-up of patients with positive tests for Human Papilloma Viruses (HPV) is rarely studied. The study objective was to compare HPV status at baseline with the outcome of CIN3+ in the follow-up period of 28 years. Materials and methods: All women referred to the HPV outpatient clinic at the University Hospital of Northern Norway (UNN) in 1990-1992, having a HPV ... -
Svangerskapsdiabetes og svangerskapsutfall ved Universitetssykehuset Nord-Norge og Nordlandssykehuset i 2004-2018
(Master thesis; Mastergradsoppgave, 2020-08-29)Innledning: Prevalens av svangerskapsdiabetes har økt de siste årene og svangerskapsdiabetes er assosiert med økt risiko for komplikasjoner under svangerskapet. I 2017 ble det innført ny faglig retningslinje for svangerskapsdiabetes. Formålet med oppgaven var å undersøke utviklingstrend i prevalens av type 1-diabetes, type 2-diabetes og svangerskapsdiabetes i vår helseregion, samt prevalens av ... -
Volumetric Arc Therapy versus Conventional Image Guided Radiotherapy in Head and Neck Cancer Patients
(Master thesis; Mastergradsoppgave, 2020-08-31)Research goal: To compare the survival outcomes, and patterns of loco-regional and metastatic recurrence of patients treated with primary radiotherapy for H&N cancer in different time periods where either conventional IGRT, IMRT or VMAT were available. Introduction: Conformal techniques are attractive for treating H&N cancer as fields may be shaped to spare critical organs. As a result, H&N ... -
Overgrepsutsattes erfaringer med spesialiserte lavterskeltilbud Symbolsk anerkjennelse, solidariske fellesskap
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-02)Et godt utbygd hjelpetilbud til overgrepsutsatte regnes i dag som et åpenbart samfunnsansvar. De ulike tiltakene som finnes, utgjør til sammen et komplekst tjenestelandskap. Denne artikkelen handler om spesialiserte lavterskeltilbud i frivillig sektor, sentre mot incest og seksuelle overgrep. I artikkelen undersøker vi hva overgrepsutsatte selv framhever som viktig og positivt ved sentrene med tanke ...
