Det helsevitenskapelige fakultet: Recent submissions
Now showing items 701-720 of 10398
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Infection of liver sinusoidal endothelial cells with Muromegalovirus muridbeta1 involves binding to neuropilin-1 and is dynamin-dependent
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)Liver sinusoidal endothelial cells (LSEC) are scavenger cells with a remarkably high capacity for clearance of several blood-borne macromolecules and nanoparticles, including some viruses. Endocytosis in LSEC is mainly via the clathrin-coated pit mediated route, which is dynamin-dependent. LSEC can also be a site of infection and latency of betaherpesvirus, but mode of virus entry into these ... -
Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIB, yet maintain a preserved fenestration the Glmp gt/gt mouse model of slowly progressing liver fibrosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-01)Liver sinusoidal endothelial cells (LSECs) are fenestrated endothelial cells with a unique, high endocytic clearance capacity for blood-borne waste macromolecules and colloids. This LSEC scavenger function has been insufficiently characterized in liver disease. The Glmp<sup>gt/gt</sup> mouse lacks expression of a subunit of the MFSD1/GLMP lysosomal membrane protein transporter complex, is born ... -
Comparing associations of handgrip strength and chair stand performance with all-cause mortality—implications for defining probable sarcopenia: the Tromsø Study 2015–2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Background Widely adopted criteria suggest using either low handgrip strength or poor chair stand performance to identify probable sarcopenia. However, there are limited direct comparisons of these measures in relation to important clinical endpoints. We aimed to compare associations between these two measures of probable sarcopenia and all-cause mortality. <p><p>Methods Analyses included 7838 ... -
HelseIArbeid – et tiltak for økt mestring og arbeidsdeltakelse? - Kvalitativ del. Følgeforskning på HelseIArbeid – Bedriftstiltaket. En brukerorientert kvalitativ, etnografisk studie fra to arbeidsplasser
(Research report; Forskningsrapport, 2023)<p>UiT Norges arktiske universitet ved Institutt for samfunnsmedisin har gjennomført følgeforskning på HelseIArbeid – Bedriftstiltaket (HIA) i Troms og Finnmark. Prosjektet er finansiert med FoU-midler fra Arbeids- og velferdsdirektoratet og interne midler fra UiT. <p>Tiltaket innebærer en satsing på helsefremmende og forebyggende kunnskapsformidling på arbeidsplassen, som grunnlag for mestring ... -
Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015
(Doctoral thesis; Doktorgradsavhandling, 2023-12-06)Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving ... -
Physical activity and survival in chronic comorbidity among adult HIV patients in Ethiopia: a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-07)Background - Antiretroviral therapy enables people living with HIV to live long lives, and these advances have transformed HIV infection from an acute to a chronic disease. Many non-communicable diseases, including type 2 diabetes, heart disease, and stroke, are influenced by physical inactivity. Therefore, the aim of this study was to assess the level of physical activity and survival in chronic ... -
Lifestyle risk factors of self-reported fibromyalgia in the Norwegian Women and Cancer (NOWAC) study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)Background While the aetiology of fibromyalgia syndrome (FM) remains unknown, lifestyle factors have been linked to the disorder. However, there are few studies on the association between lifestyle factors and FM, thus we examine the risk of self-reported fibromyalgia given selected lifestyle factors.<p> <p>Methods We used data from 75,485 participants in the Norwegian Women and Cancer study. ... -
A randomized controlled pilot study assessing feasibility and safety of a wilderness program for childhood, adolescent, and young adult cancer survivors: the WAYA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)Background The majority of childhood, Adolescent and Young Adult (AYA) cancer survivors suffers from long-lasting health issues following cancer treatment. It is therefore critical to explore effective health promotion strategies to address their needs. Exposure to nature is a promising approach to support the needs of young cancer survivors. This study investigated whether it is feasible to ... -
Sense of coherence in a general adult population in Northern Norway and its associations with oral health
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-13)Background Sense of coherence (SOC) is a global orientation to life that may affect a person’s way of acting and living within his or her life context, which can have an impact on general and oral health. The aims of this study were (i) to describe the distribution of SOC in a general adult population; (ii) to explore whether sociodemographic characteristics, oral health-related behaviours, ... -
The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-02)Background Intermittent theta burst stimulation (iTBS) when applied over the left dorsolateral prefrontal cortex (DLPFC) has been shown to be equally effective and safe to treat depression compared to traditional repetitive transcranial magnetic stimulation (rTMS) paradigms. This protocol describes a funded single-centre, double-blind, randomized placebo-controlled, clinical trial to investigate ... -
Altered plasma metabolite levels can be detected years before a glioma diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. Since gliomas are currently detected late, a liquid biopsy for early detection could affect the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 prediagnostic glioma cases and 550 healthy controls from the Northern Sweden Health and Disease ... -
The educational gradient in dental caries experience in Northern- Norway: a cross-sectional study from the seventh survey of the Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-24)Background Although, studies from Norway indicate a reduction in dental caries experience, in Northern-Norway this non-communicable oral condition is still prevalent. There is conflicting evidence of presence of social inequalities in dental caries in an adult population. Therefore, the aim of this study was to assess an association between educational level and dental caries experience in adults ... -
Family focus in mental health and social services for adults: Supporting minor children of parents in challenging life situations
(Doctoral thesis; Doktorgradsavhandling, 2023-11-30)Parental mental illness, parents’ loss of ability to work and family poverty affect children and put them at risk for adverse life outcomes. Support for and attendance to minor children and parenting in adult mental health and social services should therefore be an incorporated practice. The main aim of this thesis was to investigate the extent and quality of a family focus in these adult services. ... -
Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-04)Background Testosterone replacement therapy is known to improve sexual function in men younger than 40 years with pathological hypogonadism. However, the extent to which testosterone alleviates sexual dysfunction in older men and men with obesity is unclear, despite the fact that testosterone is being increasingly prescribed to these patient populations. We aimed to evaluate whether subgroups of men ... -
Program evaluation of a wilderness experience for adolescents facing cancer: A time in nature to heal, connect and find strength
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-03)Objective Despite advances in cancer treatment and increased survival, adolescents in treatment for cancer often suffer from psychosocial distress, negative mood, and chronic health problems. Wilderness therapy is considered a promising program to address psychosocial issues among adolescents with mental or behavioral health issues. There is little research on whether it may benefit adolescents in ... -
Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ... -
Is Dental Anxiety Associated with Oral Health-Related Quality of Life? Assessment of Statistical Significance and Clinical Meaningfulness in a Sample of Russian Medical and Dental Students
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-07)Information about oral health-related quality of life (OHRQoL) and dental anxiety (DA) in Russian young adults is scarce. We investigated how DA is associated with OHRQoL in a group of medical and dental students in North-West Russia. The study had a cross-sectional design and included 807 students aged 18–25 years who attended the Northern State Medical University in Arkhangelsk. OHRQoL and DA ... -
Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-12)Background: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. Method: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, ... -
The resilience of Jewish communities living in the diaspora: a scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)Introduction: Throughout history, Jewish communities have been exposed to collectively experienced traumatic events. Little is known about the role that the community plays in the impact of these traumatic events on Jewish diaspora people. This scoping review aims to map the concepts of the resilience of Jewish communities in the diaspora and to identify factors that influence this resilience.<p> ... -
Neurosensory and vascular symptoms and clinical findings in the hands of Arctic open-pit miners in Sweden and Norway–a descriptive study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-05)This cross-sectional study aimed to describe exposure to cold climate and hand-arm vibration (HAV) as well as neurosensory and vascular symptoms and clinical findings among open-pit Arctic miners. It was based on data from questionnaires and physical examinations, including 177 men and 75 women from two open-pit mines in Sweden and Norway (response rate 54%). Working outdoors or in an unheated ...