Det helsevitenskapelige fakultet: Recent submissions
Now showing items 721-740 of 10398
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The SOFIA pilot study: assessing feasibility and fidelity of coordinated care to reduce excess mortality and increase quality of life in patients with severe mental illness in a general practice setting; a cluster-randomised pilot trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-16)Objective - To evaluate the feasibility and fidelity of implementing and assessing the SOFIA coordinated care program aimed at lowering mortality and increasing quality of life in patients with severe mental illness by improving somatic health care in general practice.<p> <p>Design - A cluster-randomised, non-blinded controlled pilot trial.<p> <p>Setting - General Practice in Denmark.<p> ... -
Stable organization of the early lexical-semantic network in 18- and 24-month-old preterm and full-term infants: an eye-tracker study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-21)Introduction: An organized mental lexicon determines new information acquisition by orienting attention during language processing. Adult-like lexicalsemantic knowledge organization has already been demonstrated in 24-montholds. However, the outcomes of earlier studies have been contradictory in terms of the organizational capacities of 18-month-olds, thus our aim was to examine lexical-semantic ... -
High-speed TIRF and 2D super-resolution structured illumination microscopy with a large field of view based on fiber optic components
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)Super-resolved structured illumination microscopy (SR-SIM) is among the most flexible, fast, and least perturbing fluorescence microscopy techniques capable of surpassing the optical diffraction limit. Current custom-built instruments are easily able to deliver two-fold resolution enhancement at video-rate frame rates, but the cost of the instruments is still relatively high, and the physical size ... -
Pregnant Women at Low Risk of Having a Child with Fetal and Neonatal Alloimmune Thrombocytopenia Do Not Require Treatment with Intravenous Immunoglobulin
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-24)Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition in which maternal alloantibodies to fetal platelets cause fetal thrombocytopenia that may lead to intracranial hemorrhage (ICH). Off-label intravenous immunoglobulin (IVIg) has for 30 years been the standard of care for pregnant women who previously have had a child with FNAIT. The efficacy of this treatment has never ... -
Iatrogenic air embolism: pathoanatomy, thromboinflammation, endotheliopathy, and therapies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-19)Iatrogenic vascular air embolism is a relatively infrequent event but is associated with significant morbidity and mortality. These emboli can arise in many clinical settings such as neurosurgery, cardiac surgery, and liver transplantation, but more recently, endoscopy, hemodialysis, thoracentesis, tissue biopsy, angiography, and central and peripheral venous access and removal have overtaken surgery ... -
Designing digital systems for rehabilitation practices
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-22)The trajectories of patients in need of long-term rehabilitation services are extremely complex. Therefore, strengthening the rehabilitation field requires increasing organizational resilience to ensure robust processes and efficient collaboration and communication. In this study, we explored how digital systems can promote organizational resilience in rehabilitation practices. Methodologically, ... -
Surgery As a Trigger for Incident Venous Thromboembolism: Results from a Population-Based Case-Crossover Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-20)Background Surgery is a major transient risk factor for venous thromboembolism (VTE). However, the impact of major surgery as a VTE trigger has been scarcely investigated using a case-crossover design.<p> <p>Aim To investigate the role of major surgery as a trigger for incident VTE in a population-based case-crossover study while adjusting for other concomitant VTE triggers. <p>Methods We ... -
Publication status and reporting quality of case reports on acupuncture-related adverse events: A systematic reviews of case studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-30)Introduction: Case reports on acupuncture-related adverse events (AEs) have been consistently published in the literature. This review aims to assess the current publication status of case reports on acupuncture-related AEs and evaluate their reporting quality in order to identify areas for improvement.<p> <p>Methods: This study is a systematic review (SR) of case reports. Studies describing cases ... -
Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA ... -
Needling Point Location Used in Sham Acupuncture for Chronic Nonspecific Low Back Pain: A Systematic Review and Network Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-06)IMPORTANCE When sham acupuncture is set as a control in evaluating acupuncture, the sham needling technique is usually different from acupuncture. However, the sham procedure is conducted either at the same points that are used for the acupuncture group or at nonindicated points.<p> <p>OBJECTIVE To assess whether the outcome of sham acupuncture varies according to the needling points in ... -
A Knowledge Graph Framework for Dementia Research Data
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-20)Dementia disease research encompasses diverse data modalities, including advanced imaging, deep phenotyping, and multi-omics analysis. However, integrating these disparate data sources has historically posed a significant challenge, obstructing the unification and comprehensive analysis of collected information. In recent years, knowledge graphs have emerged as a powerful tool to address such ... -
Older high-cost patients in Norwegian somatic hospitals: A register-based study of patient characteristics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-04)Objective Two-thirds of the economic resources in Norwegian hospitals are used on 10% of the patients. Most of these high-cost patients are older adults, which experience more unplanned hospital admissions, longer hospital stays and higher readmission rates than other patients. This study aims to examine the individual and clinical characteristics of older patients with unplanned admissions ... -
Emplacing reablement -Co-creating an outdoor recreation model in the rural Arctic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-26)Reablement aims to enable older persons with functional decline to re-engage in meaningful activities. The benefits of engagement in outdoor activities are significant; however, reablement services primarily target function in indoor environments whereas descriptions of outdoor activities are sparse. The aim of this study was to create a model that integrates outdoor recreation into reablement. ... -
The temporal association between suicide and comorbid mental disorders in people treated for substance use disorders: a National registry study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)Background The time after contact with specialized health services for mental health and substance use is associated with an increased risk of suicide, where temporal aspects of suicide and comorbid mental disorders in patients with substance use disorders could be associated. This study aimed to examine the temporal association between time from last treatment contact to suicide and comorbid ... -
Why the belief in one’s equal rights matters: Self-respect, depressive symptoms, and suicidal ideation in Western and non-Western countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-21)The present research investigated the relationship between self-respect (i.e., a person’s belief of possessing the same rights as others) and depressive symptoms. Based on earlier longitudinal findings that self-respect fosters assertiveness and that assertiveness negatively predicts depressive symptoms, we tested these relationships in Western and non-Western countries. Additionally, we explored ... -
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)(1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency ... -
Ambulatory blood pressure as risk factor for long-term kidney function decline in the general population: a distributional regression approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-31)The results of randomized controlled trials are unclear about the long-term efect of blood pressure (BP) on kidney function assessed as the glomerular fltration rate (GFR) in persons without chronic kidney disease or diabetes. The limited duration of follow-up and use of imprecise methods for assessing BP and GFR are important reasons why this issue has not been settled. Since a long-term randomized ... -
[Report from] Joint EIFAAC/ICES/GFCM Workinggroup on eels (WGEEL)
(Research report; Forskningsrapport, 2022) -
Blood biomarkers and Type 2 Diabetes Mellitus - Repeated measurements of blood biomarkers in Type 2 Diabetes Mellitus cases and controls; longitudinal assessments and associations
(Doctoral thesis; Doktorgradsavhandling, 2023-11-24)Type 2 diabetes (T2DM) is a chronic metabolic disease and is characterised by insulin resistance and insufficient insulin secretion, resulting in hyperglycaemia. The prevalence of diabetes was estimated to be 10.5% in 2021, globally. T2DM is associated with several complications, including cardiovascular complications, degradation of nerve fibres and eyesight, and impaired kidney function, especially ... -
Circulating markers of extracellular matrix remodelling in severe COVID-19 patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-17)Background Abnormal remodelling of the extracellular matrix (ECM) has generally been linked to pulmonary inflammation and fibrosis and may also play a role in the pathogenesis of severe COVID-19. To further elucidate the role of ECM remodelling and excessive fibrogenesis in severe COVID-19, we examined circulating levels of mediators involved in various aspects of these processes in COVID-19 ...