Hypothermia-induced cardiac dysfunction (HCD), commonly seen during rewarming, is one of the feared complications of accidental hypothermia. Animal studies with phosphodiesterase (PDE) inhibitors and sodium nitroprusside have demonstrated positive effects on reversing HCD. These medications act by indirectly increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine ...

Introduction Emphasis on public involvement (PI) in health research has increased in the last 20 years. However, there is limited literature on PI in planning and conducting population-based health research. This study aims to identify child and adolescent health research priorities among children and stakeholder groups in Northern Norway by inviting PI groups to collaborate with researchers ...

Heart failure is associated with altered myocardial substrate utilization and reduced cardiac efficiency - changes that are hallmarks in heart failure independent of disease aetiology. This thesis describes remodelling in two distinct models of heart failure, namely obesity-mediated cardiomyopathy and early failure induced using a low dose angiotensin II (AngII). The reported cardiac phenotype in ...

Our research focused on assessing lipoprotein subfractions using the Lipoprint LDL® and HDL® system and evaluating metrics associated with HDL function. We examined data from four intervention trials involving high-risk patients of atherosclerotic cardiovascular disease (ASCVD). The interventions included lifestyle changes followed by bariatric surgery for morbidly obese patients, statin and ezetimibe ...

Early onset of alcohol consumption and early drunkenness, in particular, represent a risk factor for adolescents. Policy-makers and school professionals prioritize preventive alcohol interventions in schools. At the same time, the effectiveness of such interventions has been questioned. The major aim of this dissertation was to evaluate the effectiveness of school-based alcohol preventive programs ...

The aim of this thesis was to explore the effect of transcranial direct current stimulation (tDCS) as a symptom modifying treatment for Alzheimer’s disease. tDCS is a non-invasive brain stimulation technique where weak direct current is delivered to the scalp, causing neuromodulation as it reaches the cortex. Even though promising, the results of clinicals studies have been mixed. This thesis explored ...

<p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ...

NORM har i 2017 ferdigutviklet og publisert en egen interaktiv kartløsning, NORM-atlas, for presentasjon av NORM-databasen online. I det web-baserte NORM-atlaset kan man lage en tilpasset og dynamisk rapport for forekomst av antibiotikaresistens ved å velge geografisk område og tidsperiode i tillegg til type klinisk isolat, mikrobe og antimikrobielt middel. Denne nye applikasjonen gjør det raskt og ...

Driftsrapporten er en standardisert rapport som gir grunnlag for en samlet oversikt over driften av helseregistrene Folkehelseinstituttet er dataansvarlig og databehandler for. Driftsrapporten brukes også blant annet til å oppfylle enkelte av helseregistrenes forskriftsfestede meldeplikt til Datatilsynet.