Det helsevitenskapelige fakultet: Recent submissions
Now showing items 761-780 of 10398
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Temperature-dependent effects of phosphodiesterase inhibitors for cardiovascular support in hypothermic patients - Effects on cellular elimination of cAMP and cGMP
(Doctoral thesis; Doktorgradsavhandling, 2023-11-10)Hypothermia-induced cardiac dysfunction (HCD), commonly seen during rewarming, is one of the feared complications of accidental hypothermia. Animal studies with phosphodiesterase (PDE) inhibitors and sodium nitroprusside have demonstrated positive effects on reversing HCD. These medications act by indirectly increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine ... -
HPV mRNA and HPV DNA Tests in Cervical Cancer Screening
(Doctoral thesis; Doktorgradsavhandling, 2023-11-09)<p><i>Background:</i> Cervical cancer is the fourth most prevalent cancer in women worldwide. Cervical cancer screening (cytology or human papillomavirus [HPV] testing) and HPV vaccination can decrease cervical cancer incidence and mortality. However, because cytology-based screening has a low sensitivity to detect high-grade cervical lesions, several countries have replaced it with HPV test-based ... -
Our health, our research. Identifying public health research priorities among children and youth in a multiethnic population: Protocol for a community-based participatory health research priority survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)Introduction Emphasis on public involvement (PI) in health research has increased in the last 20 years. However, there is limited literature on PI in planning and conducting population-based health research. This study aims to identify child and adolescent health research priorities among children and stakeholder groups in Northern Norway by inviting PI groups to collaborate with researchers ... -
Integration and the Voluntary Sector: An Unfavourable Pairing, or the Perfect Match? - Exploring Integration Processes of Immigrants through and in the Voluntary Sector in Norway
(Doctoral thesis; Doktorgradsavhandling, 2023-11-09)This thesis explores how volunteerism and processes of and around integration interact, and where and how the voluntary sector may facilitate – or hamper – integration processes in a Norwegian setting. It thus addresses the recent shift towards everyday life integration in Norwegian policymaking. The thesis scrutinizes power relations between the various actors in the field: policymakers, voluntary ... -
Bør vi spise mer fisk – eller mindre?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22) -
Motor control and skill acquisition in pediatric physical therapy: an enactive proposal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-13)Theories of motor control and skill acquisition strongly influence and guide various fields of clinical practice. In last decades, changes in theoretical frameworks related to the conceptualization of brain plasticity, functional structures within the child, and environment have led to a revision of therapy approaches progressing from therapist-driven to child-initiated approaches. Even though ... -
Cardiac remodelling in obesity- and angiotensin II-mediated heart failure: Morphological, functional and metabolic alterations
(Doctoral thesis; Doktorgradsavhandling, 2019-10-21)Heart failure is associated with altered myocardial substrate utilization and reduced cardiac efficiency - changes that are hallmarks in heart failure independent of disease aetiology. This thesis describes remodelling in two distinct models of heart failure, namely obesity-mediated cardiomyopathy and early failure induced using a low dose angiotensin II (AngII). The reported cardiac phenotype in ... -
Modelling PCB-153 in northern ecosystems across time, space, and species using the nested exposure model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-06)There is concern over possible effects on ecosystems and humans from exposure to persistent organic pollutants (POPs) and chemicals with similar properties. The main objective of this study was to develop, evaluate, and apply the Nested Exposure Model (NEM) designed to simulate the link between global emissions and resulting ecosystem exposure while accounting for variation in time and space. NEM, ... -
Assessment of LDL and HDL Subfractions and Metrics of HDL Function in High-Risk Patients of Cardiovascular Disease: Evaluation of Four Different Interventions
(Doctoral thesis; Doktorgradsavhandling, 2023-10-27)Our research focused on assessing lipoprotein subfractions using the Lipoprint LDL® and HDL® system and evaluating metrics associated with HDL function. We examined data from four intervention trials involving high-risk patients of atherosclerotic cardiovascular disease (ASCVD). The interventions included lifestyle changes followed by bariatric surgery for morbidly obese patients, statin and ezetimibe ... -
Somatisk helse ved alvorlige psykiske lidelser: En kvalitativ studie av psykiatriske sykepleieres utfordring med å ivareta somatisk helse til pasienter med alvorlige psykiske lidelser i to kommuner i Finnmark
(Mastergradsoppgave; Master thesis, 2020-11-02)Bakgrunn og hensikt: Personer med alvorlige psykiske lidelser har en forventet levealder som er 15-20 år kortere enn befolkningen for øvrig, der tapte leveår i all hovedsak skyldes somatisk sykdom som kan forebygges og behandles. Det foreligger klare faglige og politiske føringer for bedre ivaretakelse av somatisk helse til personer med alvorlige psykiske lidelser. Psykiatriske sykepleiere innen ... -
Effectiveness of school-based alcohol preventive interventions for adolescents
(Doctoral thesis; Doktorgradsavhandling, 2015-08-21)Early onset of alcohol consumption and early drunkenness, in particular, represent a risk factor for adolescents. Policy-makers and school professionals prioritize preventive alcohol interventions in schools. At the same time, the effectiveness of such interventions has been questioned. The major aim of this dissertation was to evaluate the effectiveness of school-based alcohol preventive programs ... -
Samskapende velferdsinnovasjon – Ny kompetanse på vei mot «fellesskapskommunen»?
(Research report; Forskningsrapport, 2021)Alle kommuner er «fellesskapskommuner». Det har vært selve ideen med kommuner som institusjon helt fra fenomenet oppsto i 1830-årene og fram til vår tid. Hvorfor da en slik undertittel på rapportens førsteside? Det er fordi det i flere år har vært rettet et spesielt fokus på at velferdstjenester må utvikles mer med brukere i sentrum, som aktive partere i ulike praksisformer på ulike felt. Den nye ... -
Transcranial Direct Current Stimulation for patients with Alzheimer’s Disease - Exploring the influence of different stimulation parameters on treatment success
(Doctoral thesis; Doktorgradsavhandling, 2023-10-20)The aim of this thesis was to explore the effect of transcranial direct current stimulation (tDCS) as a symptom modifying treatment for Alzheimer’s disease. tDCS is a non-invasive brain stimulation technique where weak direct current is delivered to the scalp, causing neuromodulation as it reaches the cortex. Even though promising, the results of clinicals studies have been mixed. This thesis explored ... -
The Endothelial Cell Response to Inflammation, the Functional Role of the Endothelial-enriched Protein KANK3 and the Adipose Tissue Transcriptome
(Doctoral thesis; Doktorgradsavhandling, 2023-10-25)<p>A compilation of three complementary projects explores various facets of endothelial cell biology and transcriptomics, illuminating the intricate dynamics underlying cellular responses to specific stimuli across different tissues. <p>The first project examines how endothelial cells react to the inflammatory molecule tumour necrosis factor (TNF), by studying these cells over time after TNF ... -
A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases
(Conference object; Konferansebidrag, 2014)<p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ... -
Protocol and description of literature searches for the risk-benefit assessment of fish in the Norwegian diet. The Steering Committee of the Norwegian Scientific Committee for Food and Environment
(Research report; Forskningsrapport, 2020)Fish contains nutrients that are positive for our health. At the same time, it contains varying levels of undesirable substances that can have a negative effect on health. Undesirable substances can be found in different levels in most types of food. In a risk-benefit assessment, both the nutrients and the undesirable substances are assessed and it is evaluated whether it in total gives a more ... -
Årlig driftsrapport 2017. Norsk overvåkingssystem for antibiotikaresistens hos mikrober (NORM)
(Research report; Forskningsrapport, 2018)NORM har i 2017 ferdigutviklet og publisert en egen interaktiv kartløsning, NORM-atlas, for presentasjon av NORM-databasen online. I det web-baserte NORM-atlaset kan man lage en tilpasset og dynamisk rapport for forekomst av antibiotikaresistens ved å velge geografisk område og tidsperiode i tillegg til type klinisk isolat, mikrobe og antimikrobielt middel. Denne nye applikasjonen gjør det raskt og ... -
Kvalitetssikring av genteknologiske metoder
(Research report; Forskningsrapport, 2018-09)Kvalitetskontroll av infeksjonsserologiske metoder var tema for strategimøtet i 2016 og det er dermed naturlig å følge opp med kvalitetssikring av molekylærgenetiske metoder i år. På møtet i fjor ble det gitt detaljerte anbefalinger om validering/verifisering, internkontroller, usikkerhetsbedømmelse, gråsoner og tolkning. Genteknologiske metoder skiller seg betydelig fra serologi, og kvalitetssikr ... -
Driftsrapport 2018 - Norsk overvåkingssystem for antibiotikaresistens hos mikrober NORM
(Research report; Forskningsrapport, 2019)Driftsrapporten er en standardisert rapport som gir grunnlag for en samlet oversikt over driften av helseregistrene Folkehelseinstituttet er dataansvarlig og databehandler for. Driftsrapporten brukes også blant annet til å oppfylle enkelte av helseregistrenes forskriftsfestede meldeplikt til Datatilsynet. -
Kjønnsforskjeller innenfor utdanning og yrkesliv: et systematisk litteratursøk med sortering
(Research report; Forskningsrapport, 2020)Område for helsetjenester i Folkehelseinstituttet fikk i oppdrag av Barne-, ungdoms- og familiedirektoratet (Bufdir) å identifisere studier om årsaker til og tiltak mot kjønnsforskjeller innenfor utdanning og yrkesliv.