Polyphosphate is a procoagulant inorganic polymer of linear-linked orthophosphate residues. Multiple investigations have established the importance of platelet polyphosphate in blood coagulation; however, the mechanistic details of polyphosphate homeostasis in mammalian species remain largely undefined. In this study, xenotropic and polytropic retrovirus receptor 1 (XPR1) regulated polyphosphate in ...

Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the widespread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechanisms, transcriptional dysregulation, chemical modifications and editing, and alterations in miRNA ...

<p><i>Background</i> The Prechtl General Movement Assessment (GMA) is a reliable tool for the functional assessment of the young nervous system. It is based on a global assessment of the quality of infants' movements. In addition, detailed steps of assessment have been developed – one for preterm and term age, and one for use between 3 and 5 months. One potential benefit of such a detailed analysis ...

Following the COVID-19 pandemic, Denmark introduced repeated lockdowns of society, including outreach services and visits from social workers for people living with mental illnesses. Based on ethnographic fieldwork, in this article we explore how people with mental illness react to and manage their lives amid COVID-19 mitigations, focusing on how they experience and negotiate vulnerability at ...

Background: Digital tools for social communication have been deployed in care facilities during the COVID-19 pandemic to facilitate social connectedness between older people and their next of kin in a safe manner. This study explores how and why health care professionals facilitate the ad hoc and prompt use of a technology for social communication, known as KOMP, in care facilities in western ...

<p><i>Innledning:</i> Radiografi er et ungt fag der dokumentasjon av historien og utviklingen i Norge er begrenset. I Norge ble de første radiografene utdannet tidlig på 1970 tallet. Bakgrunnen for å starte utdanningen var mangel på røntgenassistenter, dårlig rekruttering av sykepleiere til ledige stillinger og at andre land i Vest Europa hadde startet å utdanne teknisk personale for å arbeide på ...

Background and objective: Andrographis paniculata (AP) is a traditionally used herbaceous plant, whose main active constituent is andrographolide. Andrographolide derivative medications and herbal preparations of AP are often used to treat respiratory tract infections. This study aims to systematically evaluate the safety of andrographolide derivative medications and herbal preparations of AP ...

Hjerteinfarkt og atrieflimmer er ledende årsaker til mortalitet og morbiditet globalt (1). Det norske dødsårsaksregisteret viser imidlertid at risiko for å dø av hjerte- og kar- sykdommer er mer enn halvert fra år 2000 til 2016 (2). Mannsverk et al. viste i 2012 at nedgangen i mortalitet av koronarsykdom i Tromsø skyldes en nedgang i insidens (3). Senere ble det vist at 66 % av nedgangen ...

Transition to school may be experienced as a critical event for both children and their families. Within an ecological framework of transition, the scope of the concept of school readiness in recent years has decentered from the child to the environment, including the readiness of (pre)school education to develop core skills in children. This study aims to understand the extent to which preschool ...

De fleste som vokser opp i fosterhjem, har kontakt med foreldre, og det iverksettes betydelige ressurser for å gjennomføre foreldresamvær. Dette er i tråd med samværsretten og bygger på kulturelle verdier der relasjonen mellom barn og biologiske foreldre har avgjørende betydning. Forskningslitteraturen kan hevdes å bekrefte viktigheten av foreldresamvær, men viser også at det kan være problematisk. ...