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Microbial Adaptation - Responses to External Cues
(Doctoral thesis; Doktorgradsavhandling, 2024-02-09)Bacteria can adapt to various environments because they efficiently sense and respond to external cues. This is exemplified by antibiotic resistance, a leading cause for death on a global scale. Antibiotics exert a selection pressure on bacteria, where improper use can inadvertently select for antibiotic resistance. Dissemination of antibiotic resistance throughout bacterial populations can occur ... -
Different Outcomes According to Needling Point Location Used in Sham Acupuncture for Cancer-Related Pain: A Systematic Review and Network Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-17)Numerous acupuncture studies have been conducted on cancer-related pain; however, its efficacy compared to sham acupuncture remains controversial. We confirmed whether the outcome of acupuncture differs according to the needling points of sham acupuncture for cancer-related pain. We searched 10 databases on 23 May 2023 to screen acupuncture trials using sham acupuncture or waiting list as controls ... -
Historien til kreftsykepleierstudiet i Tromsø
(Journal article; Tidsskriftartikkel, 2023)I denne artikkelen gir vi et innblikk i historien til kreftsykepleierstudiet i Tromsø – fra oppstarten på slutten av 1980-tallet ved Regionssykehuset i Tromsø (RST) og frem til i dag. Sykehuset og utdanningen har samarbeidet tett gjennom hele perioden. Samfunnsforhold og samfunnets behov for kreftsykepleiere er med som et bakteppe gjennom artikkelen. -
Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. This broad use makes PEG an attractive ‘allround’ candidate marker for the biodistribution of such PEGylated compounds. This paper presents the development of a novel strategy for ... -
Educational patterns of health behaviors and body mass index: A longitudinal multiple correspondence analysis of a middle-aged general population, 2007-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-01)Social differences in body mass index and health behaviors are a major public health challenge. The uneven distribution of unhealthy body mass index and of unhealthy behaviors such as smoking, physical inactivity, and harmful alcohol consumption has been shown to mediate social inequalities in chronic diseases. While differential exposures to these health variables have been investigated, the ... -
Forskjeller i mortalitet hos traumepasienter
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-16)Mortaliteten blant norske traumepasienter i perioden 2015–18 var på linje med de beste resultatene fra andre land, men fortsatt fant vi regionale forskjeller og forskjeller mellom sykehusnivåer. Selv om resultatene er bra, kan vi bli bedre. Traumer er den viktigste dødsårsaken for personer under 44 år på verdensbasis, også i vår del av verden. Mortalitet er et internasjonalt anerkjent effektmål ... -
Increased thromboinflammatory load in hereditary angioedema
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-10)C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin system, the complement system, the coagulation system, and the fibrinolytic system. In addition to the plasma leakage observed in hereditary angioedema (HAE), C1Inh deficiency may also affect these systems, which are important for thrombosis and inflammation. The aim of this study was to investigate the thromboinflammatory ... -
Hypothetical interventions and risk of atrial fibrillation by sex and education: application of the parametric g-formula in the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)Aims - To use the parametric g-formula to estimate the long-term risk of atrial fibrillation (AF) by sex and education under hypothetical interventions on six modifiable risk factors.<p> <p>Methods and results - We estimated the risk reduction under hypothetical risk reduction strategies for smoking, physical activity, alcohol intake, body mass index, systolic, and diastolic blood pressure in 14 ... -
Endometrial receptivity in women of advanced age: an underrated factor in infertility
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)BACKGROUND Modern lifestyle has led to an increase in the age at conception. Advanced age is one of the critical risk factors for female-related infertility. It is well known that maternal age positively correlates with the deterioration of oocyte quality and chromosomal abnormalities in oocytes and embryos. The effect of age on endometrial function may be an equally important factor influencing ... -
Physical activity behavior and its association with global cognitive function three months after stroke: The Nor-COAST study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-13)Objective - The purposes of this study were to determine the association between physical activity (PA) behavior and global cognitive function 3 months after stroke and to explore the role of physical capacity as a mediating factor.<p> <p>Methods - Participants with stroke were successively recruited at 5 different hospitals in Norway. PA was measured using accelerometers, with a follow-up period ... -
Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets
(Journal article; Tidsskriftartikkel, 2023-11-02)<p>This study investigates the influence of drug load and polymer molecular weight on the structure of tablets three-dimensionally (3D) printed from the binary mixture of prednisolone and hydroxypropyl methylcellulose (HPMC). Three different HPMC grades, (AFFINISOLTM HPMC HME 15LV, 90 Da (HPMC 15LV); 100LV, 180 Da (HPMC 100LV); 4M, 500 Da (HPMC 4M)), which are suitable for hot-melt extrusion (HME), ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
(Journal article; Tidsskriftartikkel, 2023-10-20)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed an ex vivo human whole-blood assay to evaluate liposome interactions with immune cells. We systematically varied liposome size, PEG-surface densities and sphingomyelin and ... -
Concurrent and predictive validity of the Alberta Infant Motor Scale and the Peabody Developmental Motor Scales-2 administered to infants born preterm in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)The correlation between the Alberta Infant Motor Scale (AIMS) and the Peabody Developmental Motor Scales-2 (PDMS-2) has not previously been assessed in Norwegian infants. Our purpose was to investigate the concurrent validity of the AIMS and the PDMS-2 in a group of high-risk infants, and to investigate the predictive validity of the two tests for atypical motor function at 24 months post term age ... -
SIBS Søskenprosjektet
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-17)Denne artikkelen oppsummerer kunnskapen om effekten av søskenintervensjonen SIBS til barn med kroniske helsetilstander. Intervensjonen baserer seg på familiesystemisk teori med elementer fra resiliensteori, familiekommunikasjon, forståelse av sykdom og helsekunnskap samt kognitiv atferdsterapi. Intervensjonen er et manualbasert gruppetiltak der søsken og en forelder deltar over fem økter. Tre av de ... -
Grazing incidence to total internal reflection fluorescence structured illumination microscopy enabled by a prism telescope
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-13)In super-resolution structured illumination microscopy (SR-SIM) the separation between opposing laser spots in the back focal plane of the objective lens affects the pattern periodicity, and, thus, the resulting spatial resolution. Here, we introduce a novel hexagonal prism telescope which allows us to seamlessly change the separation between parallel laser beams for 3 pairs of beams, simultaneously. ... -
Prevention of obstetric anal sphincter injuries with perineal support and lateral episiotomy: A historical cohort study
(Journal article; Tidsskriftartikkel, 2023-12-05)<p><i>Introduction</i> - There are many risk factors for obstetric anal sphincter injury (OASIS) and the interaction between these risk factors is complex and understudied. The many observational studies that have shown a reduction of OASIS rates after implementation of perineal support have short follow-up time. We aimed to study the effect of integration of active perineal support and lateral ... -
A novel serum calprotectin (MRP8/14) particle-enhanced immuno-turbidimetric assay (sCAL turbo) helps to differentiate systemic juvenile idiopathic arthritis from other diseases in routine clinical laboratory settings
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-25)Background Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We have recently validated the complex of myeloid-related proteins 8/14 (MRP8/14, also known as S100A8/A9 complex or serum calprotectin) as a helpful biomarker supporting the diagnosis ... -
The immunogenicity and safety of Group B Streptococcal maternal vaccines: A systematic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-09)Purpose: To systematically review immunogenicity and safety data of maternal group B streptococcal (GBS) vaccines in published clinical trials until July 2023.<p> <p>Methods: EMBASE, MEDLINE, Cochrane Library and clinicaltrial.gov. databases were searched for clinical studies that reported immunogenicity and/or safety of GBS vaccine in non-pregnant adults, pregnant women and infants between 1st ... -
Factors Associated with Peer Victimization Among Brazilian Low-Income Adolescents
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-16)Exposure to peer aggression and bullying victimization are both expressions of peer victimization but distinct constructs among adolescents. This study examined the potential associations between peer victimization and individual/family/peer factors and assessed whether the factors associated with peer aggression differed from those related to bullying victimization. This cross-sectional study, ... -
Risk factors for sexual harassment and abuse victimization among adolescent athletes and non-athletes: A one-year follow-up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-18)Background: The association between SHA and negative mental health increases the need to understand risk factors for SHA victimization, which is important for future development of prevention programs.<p> <p>Objective: To examine which combinations of demographic- and mental health factors were associated with subsequent SHA victimization, and the prevalence of elite athletes, recreational athletes, ...