Now showing items 421-440 of 713

    • Using medical birth registries in the Kola Peninsula for birth defects surveillance and investigation of their risk factors 

      Postoev, Vitaly Alexandrovich (Doctoral thesis; Doktorgradsavhandling, 2016-11-18)
      Medical birth registries are valuable sources of information about maternal and newborn’s health. In North-West Russia the registries were initiated in 1997 in the city of Monchegorsk and for all of Murmansk County in 2005. In this thesis we demonstrated the effectiveness of these data sources for surveillance of birth defects with the following objectives: (i) estimated changes in prevalence of ...
    • Cultivating helper qualities: Immediate and long-term impacts of mindfulness training for medical and psychology students A prospective randomized controlled study and qualitative exploration 

      Solhaug, Ida (Doctoral thesis; Doktorgradsavhandling, 2016-11-11)
      This thesis explored the immediate and long-term impact of participating in a 7-week mindfulness-based stress reduction intervention on medical and psychology students. A significant proportion of healthcare professionals experience distress and stress-related burnout, which have been linked to patient dissatisfaction, worse patient outcomes, and increased rates of medical error. Distress, ...
    • Psoriasis, overweight and metabolic syndrome. The Tromsø Study 

      Danielsen, Kjersti (Doctoral thesis; Doktorgradsavhandling, 2014-05-28)
      Recently it has been suggested that the chronic inflammatory disease psoriasis is more than skin deep, as it has been associated with several comorbid conditions, including diabetes and cardiovascular disease. Increasing prevalence of psoriasis has been observed, possibly due to changes in lifestyle. Within the population-based Tromsø study cohort, we found an increase in the self-reported prevalence ...
    • Contradictory management requirements and organisation of daily work in Norwegian nursing homes 

      Kristiansen, Margrethe (Doctoral thesis; Doktorgradsavhandling, 2016-11-04)
      Hvordan forholder ansatt i sykehjem seg til motstridende styringskrav i organisering av det daglige arbeidet? En doktorgradsavhandling ved Institutt for helse- og omsorgsfag viser at ansatte i sykehjem utvikler kreative arbeidsmåter for å klare å balansere faglige verdier med markedsideologiske styringskrav (NPM). Balanseringen innebærer etablering av ulike mestringsstrategier, utvikling av nye ...
    • Dynamic functional assessment of maternal hemodynamics in human pregnancy 

      Vårtun, Åse Lillian (Doctoral thesis; Doktorgradsavhandling, 2016-09-09)
      Pregnancy causes significant changes in maternal circulation and cardiac function. In healthy pregnancy the blood volume, heart rate, stroke volume and cardiac output are known to increase and these physiological alterations are largely complete by mid-gestation. Investigation into cardiovascular response to dynamic changes in the loading condition of heart during pregnancy might contribute to better ...
    • Experiences with outpatient commitment orders from the perspectives of patients, relatives and staff - A qualitative study 

      Stensrud, Bjørn (Doctoral thesis; Doktorgradsavhandling, 2016-10-27)
      Compulsory outpatient psychiatric care or outpatient commitment (OC) is intended to ensure treatment of people with severe psychotic disorders after discharge from inpatient care. Although OC has long been used in Norway, there is little research-based knowledge of the extent and content of the scheme and a particular lack of knowledge of the experiences of those involved. The studies are based on ...
    • Hypothalamic clock involvement in cluster headache. A study of chronobiology, sleep, and cranial autonomic function in cluster headache 

      Ofte, Hilde Karen (Doctoral thesis; Doktorgradsavhandling, 2016-10-24)
      Cluster headache has been claimed to be a chronobiological disorder because of its striking periodic occurrence. This suggests that the biological clock is involved in the pathophysiology of the disease, but few researchers have studied this in depth. In this thesis, we have studied several aspects of chronobiology in cluster headache patients. First, we assessed the periodicity of headache attacks, ...
    • Predictors and determinants for recovery and survival after upper abdominal surgery 

      Aahlin, Eirik Kjus (Doctoral thesis; Doktorgradsavhandling, 2016-10-21)
      Background: Patients with colorectal malignancies have benefited from major improvements in surgical technique and perioperative care during the last decades. These improvements have contributed to fast recovery and high survival rates. In contrast, patients with upper abdominal malignant disease often experience delayed recovery and long-standing functional impairment. Postoperative complications ...
    • Potato consumption and risk of colorectal and pancreatic cancer. The Norwegian Women and Cancer cohort and the HELGA cohort. 

      Åsli, Lene Angell (Doctoral thesis; Doktorgradsavhandling, 2016-10-14)
      Summary The present work includes participants from two cohorts: The Norwegian Women and Cancer (NOWAC) study (paper 1 and 2) and the HELGA study (paper 3). The NOWAC Study is a population-based prospective cohort study that started data collection in 1991, and consists of more than 172,000 women. The HELGA study is a population-based Scandinavian cohort, consisting of 119,978 men and women from: ...
    • Suicides in the Nenets Autonomous Okrug, Russia. 

      Sumarokov, Yury (Doctoral thesis; Doktorgradsavhandling, 2016-10-25)
      This is a study of suicides in the Nenets Autonomous Okrug (NAO), a region with a large proportion of indigenous Nenets. To our knowledge, this is the first study investigating the problem of suicide in the indigenous and non-indigenous populations of the Russian Arctic. Our study aim was to assess suicide rates in the indigenous and non-indigenous populations of the NAO, as well as the socio-demographic ...
    • Hypothermia-induced myocardial calcium overload –a study of intracellular Ca2+ handling during profound hypothermia and rewarming 

      Wold, Ragnhild Margrete (Doctoral thesis; Doktorgradsavhandling, 2016-09-30)
      We performed randomized controlled experimental studies in an intact animal model and in isolated cardiac myocytes with the following aims: To establish an in vivo model for measuring cardiac intracellular [Ca2+] ([Ca2+]i) in an anesthetized rat with maintained spontaneous circulation. In this model we could sort out if alterations in Ca2+ homeostasis take place in response to hypothermia and ...
    • The role of inflammatory pathways in neuroblastoma tumorigenesis 

      Snapkov, Igor (Doctoral thesis; Doktorgradsavhandling, 2016-09-23)
      Neuroblastoma er en type nervecellekreft hos barn. Den har en svært kompleks biologisk heterogenisitet og er i noen tilfeller resistent mot cellegift. Den aggressive varianten av neuroblastoma er vanskelig å behandle, og dødeligheten er relativ høy. Det betyr at behovet for alternative behandlingsstrategier er stort. Gjennom økt biologisk forståelse kan man utvikle mer målrettede behandlinger som ...
    • Imaging in plastic surgery. A clinical and experimental study with notes on the history of medical imaging. 

      Weum, Sven (Doctoral thesis; Doktorgradsavhandling, 2013-04-29)
      This thesis is based on four papers that have imaging techniques used in breast reconstruction as the common denominator. Each paper describes the results of a study. The purpose of the first three studies was to evaluate the use of dynamic infrared thermography (DIRT) as an imaging technique for perforator mapping in breast reconstruction with a deep inferior epigastric perforator (DIEP) flap. The ...
    • Non-beta-lactamase-mediated beta-lactam resistance in Haemophilus influenzae. Mechanisms, epidemiology and susceptibility testing 

      Skaare, Dagfinn (Doctoral thesis; Doktorgradsavhandling, 2016-05-20)
      Haemophilus influenzae is a major pathogen, with the ability to cause a wide spectrum of invasive and non-invasive infections. Beta-lactams are first-line drugs but beta- lactam resistant strains are common. Beta-lactamase (bla) producing isolates emerged in the 1970s, and non-bla-mediated resistance due to mutations in the ftsI gene encoding penicillin-binding protein 3, denoted ‘rPBP3’ in this ...
    • Resuscitate the heart and remember the brain. A prospective observational study of cognitive outcome after Out-of-Hospital Cardiac arrest 

      Ørbo, Marte Christine (Doctoral thesis; Doktorgradsavhandling, 2016-06-03)
      Cognitive outcome after out-of-hospital cardiac arrest Aim: To investigate long-term cognitive outcomes after survival from Out-of-Hospital Cardiac Arrest (OHCA) with neuropsychological assessment methods. Background: OHCA may cause cognitive impairments and functional disability due to hypoxic-ischemic brain injury. Methods: Cognitive functions, health-related quality of life and affective symptoms ...
    • Concentrations and predictors of persistent organic pollutants in pregnant women and associations with maternal and infant thyroid homeostasis. The Northern Norway Mother-and-Child Contaminant Cohort Study 

      Berg, Vivian (Doctoral thesis; Doktorgradsavhandling, 2015-12-10)
      During the 20th century, humans have been exposed to an increasing number of persistent organic pollutants (POPs). However, due to restrictions on use and the banning of several POPs, environmental concentrations of POPs have generally decreased since the 1980s. POPs are transferred to humans primarily through diet and are transferred from the mother to the foetus during pregnancy and to infants ...
    • Use of analgesics in the general population: Trends, persistence, high-risk use and associations with pain sensitivity 

      Samuelsen, Per-Jostein (Doctoral thesis; Doktorgradsavhandling, 2016-08-19)
      Background: Analgesics are commonly used drugs but we are lacking knowledge of trends, persistence, high-risk use and the association with pain sensitivity at a population-level. Purpose: To describe the use of analgesics, particularly persistent analgesic use, in a general population (30+ years), including change over time, contraindications and drug interactions, risk factors, and associations ...
    • Academic performance and student dropout. Results from two studies in upper secondary and higher education in Northern Norway 

      Sæle, Rannveig Grøm (Doctoral thesis; Doktorgradsavhandling, 2016-08-19)
      Education is important for the individual and for society. One of the most important and stable predictors of educational dropout is academic performance, typically measured by grades. This thesis aims to investigate factors related to academic performance and student dropout. It comprises two projects. The first project, Young Will (Ung vilje), is based on a sample of adolescents entering upper ...
    • Helicobacter pylori infection in the 21st century: Epidemiology, transmission and clinical aspects 

      Breckan, Ragnar K. (Doctoral thesis; Doktorgradsavhandling, 2016-06-09)
      Background: More than half the world’s population is colonized with Helicobacter pylori (H. pylori) in the gastric mucosa which is the major cause of chronic gastritis and peptic ulcer. Moreover, H. pylori has been associated with the development of non-cardia gastric cancer, the second leading cause of cancer-related deaths worldwide, and has been linked to extra-intestinal diseases, with unsettled ...
    • Glucose metabolism, genetic factors, vitamin D binding protein and directly measured free 25-hydroxyvitamin D -Results from a randomized controlled trial with high-dose vitamin D supplementation in subjects with prediabetes 

      Sollid, Stina Therese (Doctoral thesis; Doktorgradsavhandling, 2016-04-21)
      Tidligere studier har vist en sammenheng mellom vitamin D-nivåer og type 2 diabetes, men om vitamin D kan brukes for å forebygge type 2 diabetes, har ikke vært kjent. 511 personene ble inkludert i studien og jevnt fordelt til å motta enten ukentlig høy-dose vitamin D-tilskudd eller narremedisin (placebo). Etter ett år var det ingen effekt av vitamin D-tilskudd på utviklingen av type 2 diabetes ...