Artikler, rapporter og annet (medisinsk biologi): Recent submissions

Now showing items 941-960 of 1059

    • Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels 

      Parikh, H; Wang, ZM; Pettigrew, KA; Jia, JP; Daugherty, S; Yeager, M; Jacobs, KB; Hutchinson, A; Burdett, L; Cullen, M; Qi, LQ; Boland, J; Collins, I; Albert, TJ; Vatten, Lars Johan; Hveem, Kristian; Njølstad, Inger; Cancel-Tassin, G; Cussenot, O; Valeri, A; Virtamo, J; Thun, MJ; Feigelson, HS; Diver, WR; Chatterjee, N; Thomas, G; Albanes, D; Chanock, SJ; Hunter, DJ; Hoover, R; Hayes, RB; Berndt, SI; Sampson, J; Amundadottir, L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (KLK3) have been shown to be associated with both serum PSA levels and prostate cancer. Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine ...

    • HPV types, HIV and invasive cervical carcinoma risk in Kampala, Uganda : a case-control study 

      Odida, M; Sandin, S; Mirembe, F; Kleter, B; Quint, W; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      While the association of human papillomavirus (HPV) with cervical cancer is well established, the influence of HIV on the risk of this disease in sub-Saharan Africa remains unclear. To assess the risk of invasive cervical carcinoma (ICC) associated with HIV and HPV types, a hospital-based case-control study was performed between September 2004 and December 2006 in Kampala, Uganda. Incident cases of ...

    • The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor 

      Kostenko, Sergiy Viktorovich; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the ...

    • Climate change and environmental impacts on maternal and newborn health with focus on Arctic populations. 

      Rylander, Charlotta; Odland, jon Øyvind; Sandanger, Torkjel Manning (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In 2007, the Intergovernmental Panel on Climate Change (IPCC) presented a report on global warming and the impact of human activities on global warming. Later the Lancet commission identified six ways human health could be affected. Among these were not environmental factors which are also believed to be important for human health. In this paper we therefore focus on environmental factors, climate ...

    • Fish consumption and socio-economic factors among residents of Arkhangelsk city and the rural Nenets autonomous area 

      Petrenya, Natalia Nikolaevna; Dobrodeeva, Lilya; Brustad, Magritt; Bichkaeva, Fatima; Menshikova, Elena; Lutfalieva, Gulnara; Poletaeva, Anna; Repina, Veronika; Cooper, Marie; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The urban Russian and the rural Indigenous populations in the Russian European North have different lifestyles, living conditions and food supplies. The objective of this study was to investigate and compare fish consumption in relation to the socio-economic characteristics of communities in Arkhangelsk County. This is a cross-sectional study. In total, 166 adults (83.1% women) from Arkhangelsk ...

    • Physical activity and mortality among Norwegian women : the Norwegian Women and Cancer Study 

      Borch, Kristin Benjaminsen; Braaten, Tonje; Lund, Eiliv; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Physical activity (PA) and its relationship with all-cause mortality suggest a strong and consistent inverse association. This study prospectively investigated the association between PA level and mortality among participants of the Norwegian Women and Cancer (NOWAC) Study. A total of 66,136 NOWAC participants were followed-up until December 31st 2008. PA level and possible confounding factors ...

    • Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs 

      Alemu, Endalkachew; Sjøttem, Eva; Outzen, heidi; Larsen, Kenneth Bowitz; Holm, turid; Bjørkøy, Geir; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKC?/? and PKC? serve important roles during development and in processes subverted in cancer such as cell and tissue polarity, cell proliferation, differentiation and apoptosis. In an effort to identify novel ...

    • Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation. 

      Shiryaev, Alexey; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Classical mammalian mitogen-activated protein kinase (MAPK) pathways consist of a cascade of three successive phosphorylation events resulting in the phosphorylation of a variety of substrates, including another class of protein kinases referred to as MAPK-activating protein kinases (MAPKAPKs). The MAPKAPKs MK2, MK3 and MK5 are closely related, but MK2 and MK3 are the major downstream targets of the ...

    • Physical activity and bone : the importance of the various mechanical stimuli for bone mineral density : a review 

      Morseth, Bente; Emaus, Nina; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Numerous studies have reported benefits of regular physical activity on bone mineral density (BMD). The effects of physical activity on BMD are primarily linked to the mechanisms of mechanical loading, but the understanding of the precise mechanism behind the association is incomplete. The aim of this paper was to review the main findings concerning sources and types of mechanical stimuli in relation ...

    • Lønnsspiralen i fotballnæringen, en gordisk knute? 

      Bertheussen, Bernt Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Til tross for stadig større inntekter, er mange klubbøkonomier i krise. En viktig årsak til dette er at lønnskostnadene eskalerer. I denne artikkelen drøftes årsaker til lønnspresset i fotballnæringen. Fotballklubber er primært opptatt av sport og ikke av økonomi, men klubbene er avhengige av økonomiske ressurser for å kunne oppnå sportslig suksess. De beste klubbene i Tippeligaen ansetter dyre ...

    • The influence of a series of five dry cupping treatments on pain and mechanical thresholds in patients with chronic non-specific neck pain : a randomised controlled pilot study 

      Lauche, Romy; Cramer, Holger; Choi, Kyung-Eun; Rampp, Thomas; Saha, Felix Joyonto; Dobos, Gustav J.; Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In this preliminary trial we investigated the effects of dry cupping, an ancient method for treating pain syndromes, on patients with chronic non-specific neck pain. Sensory mechanical thresholds and the participants’ self-reported outcome measures of pain and quality of life were evaluated. Fifty patients (50.5 ± 11.9 years) were randomised to a treatment group (TG) or a waiting-list control group ...

    • Risk of malnutrition and health-related quality of life in community-living elderly men and women : the Tromsø study. 

      Kvamme, Jan-Magnus; Olsen, Jan Abel; Florholmen, Jon; Jacobsen, Bjarne Koster (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Purpose To explore the association between risk of malnutrition as well as current body mass index (BMI) and health-related quality of life (HRQoL) in elderly men and women from the general population. Methods In a cross-sectional population survey including 1,632 men and 1,654 women aged 65 to 87 years from the municipality of Tromsø, Norway, we assessed HRQoL by using the EuroQol (EQ-5D) ...

    • Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients 

      Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Sørbye, Sveinung Wergeland; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor receptor-3 (VEGFR-3), are strongly involved in angiogenesis. This study ...

    • The association of education with body mass index and waist circumference in the EPIC-PANACEA study 

      Hermann, Silke; Rohrmann, Sabine; Linseisen, Jakob; May, Anne M.; Kunst, Anton; Besson, Herve; Romaguera, Dora; Travier, Noemie; Tormo, Maria-José; Molina, Esther; Dorronsoro, Miren; Barricarte, Aurelio; Rodriguez, Laudina; Crowe, Francesca L.; Khaw, Kay-Tee; Wareham, Nicholas J.; van Boeckel, Petra G.A.; Bueno-de-Mesquita, H. Bas; Overvad, Kim; Jakobsen, Marianne Uhre; Tjønneland, Anne; Halkjær, Jytte; Agnoli, Claudia; Mattiello, Amalia; Tumino, Rosario; Masala, Giovanna; Vineis, Paolo; Naska, Androniki; Orfanos, Philippos; Trichopoulou, Antonia; Kaaks, Rudolf; Bergmann, Manuela M.; Steffen, Annika; Van Guelpen, Bethany; Johansson, Ingegerd; Borgquist, Signe; Manjer, Jonas; Braaten, Tonje; Fagherazzi, Guy; Clavel-Chapelon, Françoise; Mouw, Traci; Norat, Teresa; Riboli, Elio; Rinaldi, Sabina; Slimani, Nadia; Peeters, Petra H.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC, measured by trained ...

    • Physicians' messages in problematic sickness certification : a narrative analysis of case reports 

      Engblom, Monika; Alexanderson, Kristina; Rudebeck, Carl Edvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Many physicians find sickness certification tasks problematic. There is some knowledge about situations that are experienced as problematic, whereas less is understood about how physicians respond to the problems they face. One way to acquire such knowledge is to consider “reflection-in-action”, aspects of which are expressed in the physician’s interpretation of the patient’s story. The aim of this ...

    • The Prognostic Impact of TGF-beta 1, Fascin, NF-kappa B and PKC-zeta Expression in Soft Tissue Sarcomas 

      Valkov, Andrey Yurjevich; Sørbye, Sveinung Wergeland; Kilvær, Thomas Karsten; Dønnem, Tom; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Transforming growth factor-β (TGF-β), fascin, nuclear factor-kappa B (NF-κB) p105, protein-kinase C-zeta (PKC-ζ), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms involved in cell dedifferentiation. In soft tissue sarcomas, their expression profile is poorly defined and their significance is uncertain. We aimed to investigate the ...

    • The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas 

      Valkov, Andrey Yurjevich; Kilvær, Thomas Karsten; Sørbye, Sveinung Wergeland; Dønnem, Tom; Smeland, Eivind; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The PI3K/Akt pathway is involved in cellular survival pathways by inhibiting apoptotic processes and stimulating cell growth and proliferation. Its negative prognostic value has been proven in many types of cancer. In soft tissue sarcomas, the expression profiles of the PI3K/Akt pathway components are poorly defined and their significance uncertain. We aimed to investigate the prognostic impact of ...

    • Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas 

      Sørbye, Sveinung Wergeland; Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Dønnem, Tom; Smeland, Eivind; Al-Shibli, Khalid Ibrahim; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas (STS). Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting ...

    • Triage of Women with Low-Grade Cervical Lesions : HPV mRNA Testing versus Repeat Cytology 

      Sørbye, Sveinung Wergeland; Arbyn, Marc; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In Norway, women with low-grade squamous intraepithelial lesions (LSIL) are followed up after six months in order to decide whether they should undergo further follow-up or be referred back to the screening interval of three years. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures. At the University ...

    • HPV E6/E7 mRNA Testing Is More Specific than Cytology in Post-Colposcopy Follow-Up of Women with Negative Cervical Biopsy 

      Sørbye, Sveinung Wergeland; Arbyn, Marc; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      In Norway, women with negative or low-grade cervical biopsies (normal/CIN1) are followed up after six months in order to decide on further follow-up or recall for screening at three-year intervals. A high specificity and positive predictive value (PPV) of the triage test is important to avoid unnecessary diagnostic and therapeutic procedures whereas a low risk of high-grade disease among triage ...