Blar i tittel Artikler, rapporter og annet (klinisk medisin)
Viser treff 1384-1403 av 1796
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Race/ethnic differences in the associations of the Framingham risk factors with carotid IMT and cardiovascular events
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-02)Background Clinical manifestations and outcomes of atherosclerotic disease differ between ethnic groups. In addition, the prevalence of risk factors is substantially different. Primary prevention programs are based on data derived from almost exclusively White people. We investigated how race/ethnic differences modify the associations of established risk factors with atherosclerosis and ... -
Racial and Ethnic Differences in the Association Between Classical Cardiovascular Risk Factors and Common Carotid Intima-Media Thickness: An Individual Participant Data Meta-Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)BACKGROUND: The major risk factors for atherosclerotic cardiovascular disease differ by race or ethnicity but have largely been defined using populations of European ancestry. Despite the rising prevalence of cardiovascular disease in Africa there are few related data from African populations. Therefore, we compared the association of established cardiovascular risk factors with carotid-intima ... -
Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)The implementation of novel cancer immunotherapies in the form of immune checkpoint blockers represents a major advancement in the treatment of cancer, and has renewed enthusiasm for identifying new ways to induce antitumor immune responses in patients. Despite the proven efficacy of neutralizing antibodies that target immune checkpoints in some refractory cancers, many patients do not experience ... -
Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ... -
Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy: Results of a Randomized Clinical Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ... -
Radiographic markers of hip dysplasia in young adults: predictive effect of factors in early life
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-11)Background and objectives Acetabular dysplasia in young adults occurs, despite screening for developmental hip dysplasia (DDH) in the neonatal period. We aimed to examine how early life factors predict radiographic measurements of acetabular dysplasia at 18–19 years of age.<p> <p>Methods From a previous randomized trial (n=12,014; 1988–90) evaluating the role of hip ultrasound in newborn screening ... -
Radiolegen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-23)Han fikk avslag fra Teaterhøgskolen begge gangene han søkte. I dag bruker fastlege Morten Munkvik sine formidlingsevner til å lage bøker, tegneserier, sanger og radio om allmennmedisin til tusenvis av lyttere hver uke. -
Radiosynthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine- based radioligand for the imaging of phosphodiesterase 2A with positron emission tomography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-15)A specific radioligand for the imaging of cyclic nucleotide phosphodiesterase 2A (PDE2A) via positron emission tomography (PET) would be helpful for research on the physiology and disease-related changes in the expression of this enzyme in the brain. In this report, the radiosynthesis of a novel PDE2A radioligand and the subsequent biological evaluation were described. Our prospective compound ... -
Radiotherapy and the tumor stroma: the importance of dose and fractionation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Ionizing radiation (IR) is a non-specific but highly effective way to kill malignant cells. However, tumor recurrence sustained by a minor fraction of surviving tumor cells is a commonplace phenomenon caused by the activation of both cancer cell intrinsic resistance mechanisms, and also extrinsic intermediaries of therapy resistance, represented by non-malignant cells and structural components of ... -
Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: The Nordic-Baltic Bifurcation Study IV
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)<p><i>Background - </i>It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation. <p><i>Methods ... -
Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-19)<i>Background</i> - It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.<p> <p><i>Methods</i> ... -
A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-11)Some surgeons believe that infraclavicular brachial plexus blocks tends to result in supination of the hand/forearm, which may make surgical access to the dorsum of the hand more difficult. We hypothesised that this supination may be reduced by the addition of a suprascapular nerve block. In a double‐blind, randomised, placebo‐controlled study, our primary outcome measure was the amount of supination ... -
Randomized phase II trial comparing twice daily hyperfractionated with once daily hypofractionated thoracic radiotherapy in limited disease small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-23)<br>BACKGROUND: <br> Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small cell lung cancer (LD SCLC). Twice daily TRT is well documented, but not universally implemented - probably mainly due to inconvenience and concerns about toxicity. A schedule of three-week hypofractionated TRT is a commonly used alternative. This is the first randomized trial ... -
Randomized trial of a novel game-based appointment system for a university hospital venereology unit: Study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-08)Background: Chlamydia is the most common reportable sexually transmitted disease (STD) in Norway, and its incidence in the two northernmost counties has been disclosed to be nearly the double of the Norwegian average. The latest publicly available rates showed that 85.6% of the new cases were diagnosed in people under 29 years old. The information and communication technologies are among the most ... -
Randomized trial of a novel game-based appointment system for a university hospital venereology unit: Study protocol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-08)<p>Background: Chlamydia is the most common reportable sexually transmitted disease (STD) in Norway, and its incidence in the two northernmost counties has been disclosed to be nearly the double of the Norwegian average. The latest publicly available rates showed that 85.6% of the new cases were diagnosed in people under 29 years old. The information and communication technologies are among the ... -
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)<p><i>Background - </i>Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response. <p><i>Objectives - </i>This study sought ... -
A randomized trial of telemedicine efficacy and safety for nonacute headaches
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-11)<p><i>Objective</i>: To evaluate long-term treatment efficacy and safety of one-time telemedicine consultations for nonacute headaches.</p> <p><i>Methods</i>: We randomized, allocated, and consulted nonacute headache patients via telemedicine (n = 200) or in a traditional manner (n = 202) in a noninferiority trial. Efficacy endpoints, assessed by questionnaires at 3 and 12 months, included change ... -
A rapid chemokine response of macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)The role of chemokines in chronic hepatitis C virus (HCV) infection is not fully understood. The present study aimed to characterize the baseline serum concentrations and the initial β-chemokine response to treatment with interferon-α and ribavirin with respect to the final clinical outcome of virological response to treatment. Serum concentrations of alanine aminotransferase (ALT) and of the CC ... -
Rapid extrication of entrapped victims in motor vehicle wreckage using a Norwegian chain method - cross-sectional and feasibility study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of bacterial agent and an additional 2–3 days for phenotypic determination of antibiotic susceptibility pattern. With the escalating burden of antimicrobial resistance (AMR) rapid diagnostics becomes increasingly important to ...