<p>Tripartite motif family proteins (TRIMs) are a wide family of E3 ligases involved in the control of several cellular processes such as intracellular signaling, innate immunity, transcription, cell cycle regulation and carcinogenesis. In recent years, some members of this family have been found to have a role in autophagy. <p>The central theme of this thesis is the role of two TRIM proteins in ...

Ovarian reserve is a key component influencing reproductive function and fertility. Serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are established quantitative markers of ovarian reserve. The overall aim of this thesis comprising four work packages was to study the role of AMH and AFC on different aspects of fertility and fertility treatment. Their specific objectives were: 1) To ...

<p>During the Korean War (1951-53), Norway operated and staffed a surgical field hospital at the front along the 38th parallel. The Norwegian Mobile Army Surgical Hospital – NORMASH – was a part of the United Nations peace-enforcing force to stop aggression from North-Korea towards South-Korea. <p>NORMASH was staffed only with civilian volunteers. Without any training as a military group or in war ...

The cognitive profile associated with schizophrenia has long been a research subject of interest. A plethora of studies have not only revealed cognitive deficits but also cognitive biases, meaning qualitative deviations in the way information is processed and evaluated. Such biases are for example reflected in findings of diminished metacognitive accuracy, or premature and disadvantageous decision-making. ...

Although the problem of cardiovascular disease (CVD) in Russia has been the subject of attention for decades, a definitive and comprehensive explanation of why the CVD burden there is so high and generally greater than in many other countries has still not been found. In this thesis, I have attempted to advance research on these issues by examining the role of blood lipids, heart damage biomarkers ...

Avhandlingen består av seks artikler basert på studier fra sykepleierutdanning i Finnmark, og belyser ulike aspekter ved sykepleierutdanningens samfunnsoppdrag. Hensikten med artiklene er å bidra til økt kunnskap om urfolksperspektiv, utfordringer som stabilisering og rekruttering av sykepleiere til distriktene, samhandling mellom primær- og spesialisthelsetjeneste, samt pedagogiske tilnærminger ...

<p><i>Introduction:</i> Low-density lipoprotein (LDL) apheresis is used for the removal of LDL in selected patients and is also used for other medical indications. This thesis aimed to systematically study how different LDL apheresis systems affected the immune system in a biocompatibility perspective under in vivo and ex vivo conditions. <p><i>Methods:</i> Whole blood adsorption, dextran sulfate ...

The present thesis has investigated the cross-sectional and prospective associations between self-reported and objectively measured physical activity with five objectively measured indices of body composition in Norwegian adolescents participating in the Tromsø Study Fit: Futures Cohort. The three included papers used regression analyses to assess the cross-sectional association between self-reported ...

<i>Staphylococcus aureus</i> and <i>Enterococcus faecium</i> are opportunistic pathogens that may cause diseases ranging from minor skin infection to severe blood stream infections. The emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and vancomycin-resistant enterococcal strains severely limits treatment options. Bacteria release extracellular vesicles (EVs), defined as ...

Acute intermittent porphyria (AIP) is a rare autosomal dominant inherited metabolic disease with lowered function of the enzyme hydroxymethylbilan synthase due to mutation in this gene of the heme synthesis. The resulting excess of aminolevulinic acid and porphobilinogen can result in acute abdominal pain, paresis, fatigue, increased risk for kidney failure and hepatocellular carcinoma. Some drugs, ...