Blar i tittel Institutt for farmasi

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    • Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance 

      Vanic, Zeljka; Jøraholmen, May Wenche; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)
      Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ...

    • Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver? 

      Vanic, Zeljka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ...

    • Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species 

      Domingues, Sara; Harms, Klaus; Fricke, W. Florian; Johnsen, Pål Jarle; da Silva, Gabriela J.; Nielsen, Kåre M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains of the genera Acinetobacter, Citrobacter, Enterobacter, Escherichia, Pseudomonas, ...

    • Naturlegemidler og plantebaserte legemidler - endringer i omsetning og lovgivning i perioden 2003-2011 

      Kulagin, Ilya (Master thesis; Mastergradsoppgave, 2013-05-20)
      Alternativ medisin har vesentlig interesse utenfor skolemedisin. Preparater fra naturen er et populært eksempel på alternative behandlingsmetoder. Markedet for naturmedisin er stort. I perioden fra 2003 til 2011 har det skjedd en del endringer i lovgivningen omkring naturlegemidler som kan påvirke forbruket. En deskriptiv studie av omsetning av naturlegemidler i perioden 2003-2011 er basert på ...

    • Naturlegemidler. Omsetning og lovgivning 

      Waaseth, Marit (Master thesis; Mastergradsoppgave, 2004-12-02)
      Naturlegemidler – omsetning og lovgivning Bakgrunn Bruk av naturmidler øker i vestlige land inkludert Norge. Urtemedisin brukes vanligvis som egenbehandling, men interessen er økende også i etablert helsevesen. Naturlegemiddelordningen ble opprettet i 1994 for å gi et mer oversiktlig naturmiddelmarked. Salgsomfang og bruk av naturlegemidler er ikke kartlagt i særlig grad og lovgivningen omkring ...

    • Network Analysis: an approach to the study of drug-drug relations. Co-medication in Norwegian elderly and severe drug-drug interactions as examples 

      Askar, Mohsen (Master thesis; Mastergradsoppgave, 2019-05-15)
      Network analysis (NA) has been used for studying many social aspects. Employing of network analysis as an approach in the field of public health, to study the relations between patients or health workers and their potential effects in many medical perspectives, took a good share of researchers’ efforts as well. Few attempts have been conducted to use network analysis to study drug-drug relations ...

    • A new preparation method for preparation of liposomes-in-hydrogels primed for treatment of skin diseases 

      Ingebrigtsen, Sveinung Gaarden; Johansen, Kurt Jonny; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Conference object; Konferansebidrag, 2014)
      <p>Liposomes are spherical vesicles that form spontaneously when phospholipids are dispersed in an aqueous medium. However, to get liposomes with a more unimodal size distribution, liposomes are usually processed further to reduced size and lammellarity, typically by extrusion, sonication or homogenization. <p>Liposome formulations for topical application needs a vehicle to assure the desirable ...

    • No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study 

      Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)
      <i>Background</i> - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.<p> <p><i>Methods</i> - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. ...

    • No effect of natural transformation on the evolution of resistance to bacteriophages in the Acinetobacter baylyi model system. 

      Mcleman, Amy; Sierocinski, Pawel; Hesse, E; Buckling, A; Perron, G; Hülter, Nils Fredrik; Johnsen, Pål Jarle; Vos, M (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The adaptive benefits of natural transformation, the active uptake of free DNA molecules from the environment followed by incorporation of this DNA into the genome, may be the improved response to selection resulting from increased genetic variation. Drawing analogies with sexual reproduction, transformation may be particularly beneficial when selection rapidly fluctuates during coevolution with ...

    • The Norwegian Society for Pharmacoepidemiology 

      Lupattelli, Angela; Karlstad, Øystein; Engeland, Anders; Småbrekke, Lars; Olsen, Kristine; Øvrebust, Aina; Waaseth, Marit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      The Norwegian Society for Pharmacoepidemiology (NFFE) is a multidisciplinary, nation-wide network of professionals involved in the field of pharmacoepidemiology. Pharmacoepidemiology is the science that bridges epidemiologic methodology with clinical pharmacology and clinical pharmacy, for studying the use, effectiveness, value and safety of pharmaceuticals1 . The foundation of NFFE took into ...

    • A Novel Approach for the Treatment of Aerobic Vaginitis: Azithromycin Liposomes-in-Chitosan Hydrogel 

      Cacic, Ana; Amidžic Klaric, Daniela; Keser, Sabina; Radikovic, Maja; Rukavina, Zora; Jøraholmen, May Wenche; Uzelac, Lidija; Kralj, Marijeta; Skalko-Basnet, Natasa; Segvic Klaric, Maja; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-28)
      Biocompatible mucoadhesive formulations that enable a sustained drug delivery at the site of action, while exhibiting inherent antimicrobial activity, are of great importance for improved local therapy of vaginal infections. The aim of this research was to prepare and evaluate the potential of the several types of azithromycin (AZM)-liposomes (180–250 nm) incorporated into chitosan hydrogel (A ...

    • Novel in situ gel-forming solid dosage form (gfSDF) prepared by the simple syringe-based moulding: A screening study 

      Falavigna, Margherita; Skalko-Basnet, Natasa; Cavallari, Cristina; Pini, Andrea; Luppi, Barbara; Di Cagno, Massimiliano Pio (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-05)
      The aim of this study was to prepare and optimize a novel type of in situ gel-forming solid dosage form (gfSDF) to be used in the treatment of mucosal/skin ulcerations. For this purpose, a simple but reliable syringe-based hot melt/moulding method was employed. Chloramphenicol (antibiotic) and ibuprofen (anti-inflammatory) were chosen as model active pharmaceutical ingredients (APIs) to be loaded ...

    • Novel liposome formulation from algae membranes as carriers for bioactive compounds 

      Troyan, Anna Nikolaevna (Master thesis; Mastergradsoppgave, 2014-05-20)
      Liposomes are lipid-based systems which have the ability to incorporate various chemical substances and thus can be used for drug delivery purposes. Liposomes are composed of phospholipids, flexible in composition, and have shown great potential to improve delivery and targeting of bioactive substances which otherwise have poor bioavailability in the body. Conventional liposomes composed of various ...

    • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

      Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
      DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...

    • De novo sequencing of disulphide rich peptides using tandem mass spectrometry 

      Chala, Regasa (Master thesis; Mastergradsoppgave, 2015-05-13)
      Peptide based drugs have been shown to have better target selectivity and thereby better safety profile than many small molecule drug candidates. This led many researchers and drug companies to show an increasing interest toward bioactive peptides. Developing an effective analytical method for peptide /protein structural identification is a cornerstone to meet this expanding area of research in this ...

    • Nucleic acid peptide nanogels for the treatment of bacterial keratitis 

      Obuobi, Sybil Akua Okyerewa; Mayandi, Venkatesh; Nurul, Azlyn Mohd Nor; Lee, Benedict Jiasheng; Lakshminarayanan, Rajamani; Pui Lai, Rachel Ee (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)
      Cage-shaped nucleic acid nanocarriers are promising molecular scaffolds for the organization of polypeptides. However, there is an unmet need for facile loading strategies that truly emulate nature's host–guest systems to drive encapsulation of antimicrobial peptides (AMPs) without loss of biological activity. Herein, we develop DNA nanogels with rapid in situ loading of L12 peptide during the thermal ...

    • Nucleic acids hybrids as advanced antibacterial nanocarriers 

      Obuobi, Sybil Akua Okyerewa; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-08)
      Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by ...

    • Ny diagnostikk for Alzheimers i Nytt Senter 

      Fjellaksel, Richard; Hjelstuen, Ole Kristian; Sundset, Rune (Chronicle; Kronikk, 2015-04-23)

    • Old drug, new wrapping – A possible comeback for chloramphenicol? 

      Ingebrigtsen, Sveinung Gaarden; Didriksen, Alena; Johannessen, Mona; Skalko-Basnet, Natasa; Holsæter, Ann Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-12)
      The antimicrobial drug chloramphenicol (CAM) exhibits activity against resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). However, its use has been limited due to its toxicity. As the threat of antibiotic resistance continues to grow, a promising approach might be to increase the use of historical antimicrobial agents that demonstrate clinical efficacy, but are hampered ...

    • On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer 

      Boudghene-Stambouli, Fadia; Soulez, Mathilde; Ronkina, Natalia; Dörrie, Anneke; Kotlyarov, Alexey; Seternes, Ole Morten; Gaestel, Matthias; Meloche, Sylvain (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-21)
      ERK3 and ERK4 define a distinct and understudied subfamily of mitogen-activated protein kinases (MAPKs). Little is known about the physiological roles of these atypical MAPKs and their association with human diseases. Interestingly, accumulating evidence points towards a role for ERK3 and ERK4 signaling in the initiation and progression of various types of cancer. Notably, a recent study reported ...