Blar i tittel Institutt for farmasi

Viser treff 639-652 av 652

    • The Vaginal-PVPA: A Vaginal Mucosa-Mimicking In Vitro Permeation Tool for Evaluation of Mucoadhesive Formulations 

      Falavigna, Margherita; Pattacini, Martina; Wibel, Richard; Sonvico, Fabio; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-19)
      Drug administration to the vaginal site has gained increasing attention in past decades, highlighting the need for reliable in vitro methods to assess the performance of novel formulations. To optimize formulations destined for the vaginal site, it is important to evaluate the drug retention within the vagina as well as its permeation across the mucosa, particularly in the presence of vaginal fluids. ...

    • Validering av selvrapportert legemiddelbruk hos deltakere med koronarsykdom i Tromsøundersøkelsen 

      Truong, Kieu Nhi Lise (Mastergradsoppgave; Master thesis, 2020-05-14)
      Bakgrunn: Hjerte- og karsykdommer er en fellesbetegnelse for sykdommer som involverer hjerte og blodårer. Det er en ledende årsak til død over hele verden. Flere epidemiologiske studier utføres for å undersøke årsakene til den økte sykdomsbelastningen. Ved å studere befolkningens mønster av legemiddelbruk og videre korrigere for feilbruk, kan vi redusere risikoen for nye hendelser og progresjon av ...

    • Validering og bruk av et verktøy for å vurdere kvalitet i sekundærprofylaktisk behandling ved hjerte- kar sykdom 

      Skare, Erik Eidem (Master thesis; Mastergradsoppgave, 2009-06)
      Bakgrunn: Masteroppgaven er en del av et doktorgradsprosjekt for utvikling av en klinisk farmasøytisk service for pasienter med etablert CHD. Legemiddelrelaterte problemer kan gi økte kostnader og redusert klinisk effekt av medisinsk behandling, og gode verktøy for vurdering av kvalitet i legemiddelbehandling er mangelvare. Forekomsten av CHD er økende i den vestlige verden, og en økende andel av ...

    • vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding 

      Tran, Vi Ngoc-Nha; Shams, Alireza; Ascioglu, Sinan; Martinecz, Antal; Liang, Jingyi; Clarelli, Fabrizio; Mostowy, Rafal; Cohen, Ted; Abel zur Wiesch, Pia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)
      Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ...

    • Veitrafikkulykker knyttet til forskrivning av legemidler : En registerbasert kohortstudie 

      Skurtveit, Svetlana; Engeland, Anders; Bramness, Jørgen G.; Mørland, Jørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

    • Virtual screening and in vitro evaluation of putative positive allosteric modulators of the GABAB receptor 

      Issifou, Ibrahim Toure (Mastergradsoppgave; Master thesis, 2020-05-14)
      -aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the central nervous system (CNS). GABA exhibits its function by binding to either the ionotropic GABAA receptor or the metabotropic GABAB receptor, causing a decrease in activity in the nervous system. Disruption in the GABAergic system has been associated with various neurological conditions, including Alzheimer’s disease, anxiety, ...

    • Vurdering av publikasjonen: “Long term toxicity of a Roundup herbicide and a Rounduptolerant genetically modified maize” (Séralini et al. (2012), Food Chem Toxicol 50*). Uttalelse fra Faggruppen for genmodifiserte organismer i Vitenskapskomiteen for mattrygghet 

      Nerland, Audun Helge; Bakke, Anne Marie; Bernhoft, Aksel; Rivedal, Edgar; Torp, Torfinn; Brandtzæg, Per; Holck, Askild Lorentz; Junttila, Olavi; Konestabo, Heidi Sjursen; Meadow, Richard; Mikalsen, Arne; Nielsen, Kaare Magne; Sipinen, Ville Erling; Sorteberg, Hilde-Gunn Opsahl; Vikse, Rose; Andreassen, Åshild Kristine (Research report; Forskningsrapport, 2012-12-20)
      Den 19. september 2012 ble det publisert en artikkel i det tyske tidsskriftet «Food and Chemical Toxicology» som vakte oppmerksomhet i store deler av verden. Artikkelen bygger på en toårig fôringsstudie med rotter og konkluderer med en antatt økt hyppighet for ulike svulstdannelser og nyrelidelser blant dyrene knyttet til den genmodifiserte maisen NK603 og plantevernmidlet Roundup som inneholder ...

    • What do Australian consumers, pharmacists and prescribers think about documenting indications on prescriptions and dispensed medicines labels?: A qualitative study 

      Garada, Mona; McLachlan, Andrew J; Schiff, Gordon D; Lehnbom, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
      Background: Documenting the indication on prescriptions and dispensed medicines labels is not standard practice in Australia. However, previous studies that have focused on the content and design of dispensed medicines labels, have suggested including the indication as a safety measure. The aim of this study was to investigate the perspectives of Australian consumers, pharmacists and prescribers ...

    • Zebrafish and safety pharmacology. Effects of ethanol on early brain and eye development. 

      Ali, Amina Mohammed (Master thesis; Mastergradsoppgave, 2014-05-21)
      Ethanol is well studied with regard to its teratogenic effects in different animal models including humans. Exposure of a fetus to alcohol during pregnancy can lead to fetal alcohol syndrome (FAS), or ethanol mediated toxicity in animal models. During early embryogenesis, development of the most important organs including the central nervous system (CNS) occurs. Disturbance of any function that ...

    • Zebrafish as a model system for safety pharmacology, using a glucocorticoid and an antimicrobial peptide as test substances 

      Albert, Ingrid (Master thesis; Mastergradsoppgave, 2013-05-20)
      The zebrafish is an exciting model organism with a lot to offer and many possible areas of application. Toxicity assays using zebrafish embryos are becoming increasingly popular with the pharmaceutical industry as a tool to bridge the gap between conventional cell based screens and animal testing. The main aim of this project was to explore the zebrafish as a model system for use in safety pharmacology, ...

    • ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo 

      Samuelsen, Ørjan; Åstrand, Ove Alexander Høgmoen; Frøhlich, Christopher; Heikal, Adam; Skagseth, Susann; Carlsen, Trine Josefine Olsen; Leiros, Hanna-Kirsti S.; Bayer, Annette; Schnaars, Christian; Kildahl-andersen, Geir; Lauksund, Silje; Finke, Sarah; Huber, Sandra; Gjøen, Tor; Andresen, Adriana Magalhaes Santos; Økstad, Ole Andreas; Rongved, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
      Carbapenem-resistant Gram-negative pathogens are a critical public health threat and there is an urgent need for new treatments. Carbapenemases (β-lactamases able to inactivate carbapenems) have been identified in both serine β-lactamase (SBL) and metallo-β-lactamase (MBL) families. The recent introduction of SBL carbapenemase inhibitors has provided alternative therapeutic options. Unfortunately, ...

    • Zwitterionic antimicrobial nanoparticles for biofilm therapy 

      Phung, Anna Ngoc (Mastergradsoppgave; Master thesis, 2021-05-10)
      In recent years, many pathogenic bacteria have developed resistance against the existing antimicrobials, a phenomenon known as antimicrobial resistance (AMR). One of the many reasons contributing to the observed failure of current therapies, is the poor drug penetration across the microbial biofilm. Biofilms are small structural communities of bacterial cells that excrete an extracellular polymeric ...

    • α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal 

      Ausbacher, Dominik; Miller, Lindsey A.; Goeres, Darla M.; Stewart, Philip S.; Strøm, Morten Bøhmer; Fallarero, Adyary (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-25)
      Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms. Biofilm control is ...

    • β-cyclodextrin polymers as cholesterol sequestrating agents 

      Fadeev, Nikolay Olegovich (Master thesis; Mastergradsoppgave, 2018-08-19)
      Summary Elevated serum cholesterol blood levels is one of the central risk factors for cardiovascular diseases. Lowering blood cholesterol have significant impact on lowering cardiovascular disease events. Inhibiting cholesterol absorption in small intestine can significantly lower serum cholesterol levels and thereby - lower cardiovascular events. Β-cyclodextrin (βCD)-dextran polymer is expected ...