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Analyser av DKK3 som mulig målgen for Pax6
(Master thesis; Mastergradsoppgave, 2011-06-06)Pax6 og Pax6(5a) er to isoformer av den evolusjonært konserverte transkripsjonsfaktoren som blir uttrykt i blant annet hjernen, øyne, nese og pankreas hos virveldyr under embryoutvikling. Uttrykket av Pax6 vil vedvare hos voksne individer, blant annet i øyne, hjernen og pankreas. Den er viktig for vedlikehold av stamceller, men har også en stor betydning for celle differensiering i mange vev. Aniridia ... -
Analysis of Bottlenecks in Experimental Models of Infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-11) -
Analysis of selected benzodiazepines in the environment by HF-LPME and LC-MS/MS
(Master thesis; Mastergradsoppgave, 2009-05)Industrial chemicals, pesticides and other similar compounds are all known to be a burden for the environment. In high concentrations they can all affect the biological environment in a manner that is dangerous for organisms. The presence of pharmaceuticals and personal care products (PPCPs) in the environment are of great interest regarding to their potential toxicity. Pharmaceuticals and PPCPs are ... -
The analysis of the interaction between hepcidin and ferroportin
(Mastergradsoppgave; Master thesis, 2009-05-20)Iron homeostasis is regulated by the interaction between the hormone hepcidin and the iron exporter ferroportin. Hepcidin is a cysteine-rich peptide which is secreted by hepatocytes in response to inflammation, eryhropoietic demand and iron stores. Hepcidin binds to its receptor ferroportin, inducing its internalisation and degradation, thus regulating the export of iron from cells to plasma. One ... -
Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: a correlation study between micro-CT angiography and DCE-MRI
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)Purpose: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. Methods: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n=9), AVX235-treated ... -
Anti-osteoporotic drug use and quality of life in persons with osteoporosis – The Tromsø Study
(Master thesis; Mastergradsoppgave, 2017-05-15)Introduction: Osteoporosis is characterized by decreased bone mineral density (BMD) and is a risk factor for hip, wrist, and vertebral fractures. Fragility fractures lead to increased mortality, morbidity, pain, immobility, social isolation and depression, which all may affect the quality of life (QoL). Use of anti-osteoporotic drugs (AOD) reduces the risk of fractures and may influence QoL. Objective: ... -
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-07)<b>Background</b> <br> Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the anti-angiogenic effects of a specific cPLA2α inhibitor, AVX235, in a patient-derived ... -
Antibacterial use by birth year and birth season in children 0-2 years in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)Introduction: Consumption of antibacterials in children follows seasonal cycles, and time to first treatment depends on birth season. The aim of this study was to describe dispensing rate, one-year periodic prevalence, and age at first prescription in children aged 0-2 years in Norway. Methods: We used data from the Norwegian prescription database and included all dispensed prescriptions on systemic ... -
Antibakterielle midler til systemisk bruk til barn i aldersgruppen 0-5 år i Norge og Emilia-Romagna. En populasjonsbasert studie
(Master thesis; Mastergradsoppgave, 2016-05-12). -
Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better
(Journal article; Preprint; Tidsskriftartikkel; Peer reviewed; Manuskript, 2015-06-25)To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ... -
Antibiotikaforbruk til barn ved Rikshospitalet : målemetoder og analyse av forbruk i klinisk praksis
(Master thesis; Mastergradsoppgave, 2008-05)Bakgrunn: Ved Rikshospitalet har man fulgt forbruket av antibiotika nøye i en årrekke ved å benytte data fra sykehusapotekets legemiddelleveranser, som er basert på måleenheten definerte døgndoser (DDD). Bakgrunnen for dette prosjektet var et ønske fra Avdeling for sykehushygiene om å undersøke forbruket hos barn nærmere, da det er flere årsaker til at DDD ikke er en passende måleenhet for denne ... -
Antibiotikaforskrivning ved samfunnservervet pneumoni og KOLS-eksaserbasjon ved Universitetssykehuset Nord-Norge
(Master thesis; Mastergradsoppgave, 2019-05-15)<p>Bakgrunn: Rasjonell antibiotikaforskrivning, som i denne sammenheng vil si i henhold til Nasjonal faglig retningslinje for antibiotikabruk i sykehus, er et av de viktigste tiltakene vi har for å motvirke resistensutvikling. Forskrivning i henhold til retningslinjer er også assosiert med gunstige pasientutfall. Samfunnservervet pneumoni (community-acquired pneumonia; CAP) og kronisk obstruktiv ... -
Antibiotikaprofylakse ved kirurgi : kartlegging og analyseverktøy
(Master thesis; Mastergradsoppgave, 2008-05-20)Bakgrunnen for oppgaven er økt oppmerksomhet rundt riktig antibiotikabruk. Antibiotika har i snart 30 år blitt brukt som profylakse i forbindelse med kirurgiske inngrep for å redusere morbiditet og mortalitet forårsaket av postoperative infeksjoner. Thoraxkirurgisk avdeling på Rikshospitalet fikk i februar 2007 nye retningslinjer for bruk av antibiotikaprofylakse ved kirurgiske inngrep. Formål Hensikten ... -
Antibiotikaresistens - kunnskapshull, utfordringer og aktuelle tiltak. Rapport fra tverrsektoriell ekspertgruppe
(Research report; Forskningsrapport, 2014) -
Antimicrobial resistance acquisition via natural transformation: context is everything
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. Although this mechanism is known to mediate the uptake of antibiotic resistance determinants in a range of human pathogens, its importance in the spread of antimicrobial resistance is not always appreciated. ... -
Are ready for Market Genetically Modified, Conventional and Organic Soybeans Substantially Equivalent as Food and Feed?
(Chapter; Bokkapittel, 2015)Important compositional elements, including residues of herbicides, were investigated in commercial soy varieties grown within the same geographical area. These included genetically modified, conventional and organic soybeans. Feed made from these soybeans was subsequently fed to the model organism Daphnia magna, while measuring the fitness performance (survival, growth and reproduction) during the ... -
Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption : an individual-level prescription database study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2007-12-05)Background: A previous study has shown that variations in threshold and intensity (lipid goal attainment) of statins for primary prevention contribute to regional differences in overall consumption of statins in Norway. Our objective was to explore how differences in prevalences of use, dosing characteristics, choice of statin and continuity of therapy in individual patients adds new information ... -
Assessing Potentially Inappropriate Medications in Nursing Home Residents by NORGEP-NH Criteria
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-05)<p><i>Background</i>: Nursing home residents often have several conditions that necessitate the use of multiple medicines. This study investigates the prevalence of potentially inappropriate medications (PIMs) and its associations with sex, age, number of medicines, and study location (rural/urban).</p> <p><i>Methods:</i> A cross-sectional study of long-term care residents from six nursing ... -
Assessing the probability of detection of horizontal gene transfer events in bacterial populations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Experimental approaches to identify horizontal gene transfer (HGT) events of non-mobile DNA in bacteria have typically relied on detection of the initial transformants or their immediate offspring. However, rare HGT events occurring in large and structured populations are unlikely to be detected in a short time frame. Population genetic modeling of the growth dynamics of bacterial genotypes is ... -
Association between the use of Proton Pump Inhibitors and Histamine-2 Receptor Antagonists and the risk of gastric cancer in Norway
(Master thesis; Mastergradsoppgave, 2021-05-13)Background: The use of proton pump inhibitors (PPIs) on prescription has increased over the last decade in Norway. PPIs are an important medication in the treatment of acid related disorders such as peptic ulcer disease, gastroesophageal reflux disease and Helicobacter Pylori (H. Pylori) infection. However, many previous studies have raised concern about the potential risk of gastric cancer following ...
